700349-68-4

Upstream product

• 123-54-6 acetylacetone 
• 3043-28-5 3-bromopentane-2,4-dione 
• 19250-09-0 3,4-dichlorophenylthiourea 
• 1694-29-7 3-chloropentane-2,4-dione 

Downstream Products

• 1257438-53-1 1-[2-(3,4-dichloro-phenylamino)-4-methyl-thiazole-5-yl]-3-(3,4-methylenedioxyphenyl)-propen-1-one 
• 1257438-50-8 1-[2-(3,4-dichloro-phenylamino)-4-methyl-thiazole-5-yl]-3-(4-chlorophenyl)-propen-1-one 
• 1257438-54-2 1-[2-(3,4-dichloro-phenylamino)-4-methyl-thiazole-5-yl]-3-(3,4,5-trimethoxyphenyl)-propen-1-one 
• 1257438-49-5 1-[2-(3,4-dichloro-phenylamino)-4-methyl-thiazole-5-yl]-3-phenyl-propen-1-one 
• 1257438-51-9 1-[2-(3,4-dichloro-phenylamino)-4-methyl-thiazole-5-yl]-3-(4-methoxyphenyl)-propen-1-one 
• 1257438-52-0 1-[2-(3,4-dichloro-phenylamino)-4-methyl-thiazole-5-yl]-3-(3-methoxyphenyl)-propen-1-one 
• 1286278-99-6 3-dimethylamino-1-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}propenone 
• 1333391-43-7 (4-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-(3-methoxyphenyl)amine 
• 1333391-36-8 (4-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-(3-chlorophenyl)amine 
• 1333391-42-6 (4-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-o-tolylamine 
• 1286278-97-4 (4-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-m-tolylamine 
• 1333391-35-7 (4-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-N-phenylamine 

Relevant academic research and scientific papers

Synthesis of novel thiazolyl-pyrimidines and their anticancer activity in vitro

A series of novel compounds 7-43 were prepared via the condensation of enaminones 4a-h and the guanidines carbonate 6a-f. The structures of these newly synthesized compounds were confirmed by 1H-NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL-7404, SPC-A-01 and SGC-7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549. Thiazolyl-pyrimidines were synthesized by the general pyrimidine condensation of Bredereck and their in-vitro anticancer activities were evaluated. Copyright

Study on condensation of N-aryl thioureas with 3-bromo-acetylacetone: Synthesis of aminothiazoles and iminodihydrothiazoles, and their in vitro antiproliferative activity on human cervical cancer cells

The condensation of N-aryl thioureas with 3-bromo-acetylacetone in neutral solvent acetone not only led to 5-acetyl-4-methyl-2-(substituted anilino) thiazoles 3 but also 2-imino-3-(substituted phenyl)-4-methyl-5-acetyl-2,3- dihydrothiazoles 4. Further study found that different reaction solvents displayed an important role toward the ratio of aminothiazoles 3 and iminodihydrothiazoles 4, and the reaction scope was extended. A plausible mechanism involving solvent effect and in situ hydrobromic acid catalyzation was proposed. Some selected isomers exhibited moderate in vitro antiproliferative activity on human cervical cancer cell lines (Hela, Siha).

Synthesis and anticancer evaluation of thiazolyl-chalcones

Thirty-seven (E)-1-(4-methyl-2-arylaminothiazol-5-yl)-3-arylprop-2-en-1- ones were synthesized via Claisen-Schmidt condensation of 1-(4-methyl-2- (arylamino)thiazol-5-yl)ethanone with the corresponding arylaldehydes. All these thiazolyl-chalcones were cha