1333391-35-7

Basic information

• Product Name: (4-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-N-phenylamine
• CAS NO: 1333391-35-7
• Molecular Weight: 442.371
• Mol File: 1333391-35-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-N-phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-N-phenylamine(1333391-35-7)
• EPA Substance Registry System: (4-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-N-phenylamine(1333391-35-7)

Safety Data

• Hazardous Substances Data: 1333391-35-7(Hazardous Substances Data)

Upstream product

• 700349-68-4 1-(2-(3,4-dichlorophenylamino)-4-methylthiazol-5-yl)ethanone 
• 1286278-99-6 3-dimethylamino-1-{2-[(3,4-dichlorophenyl)(methyl)amino]-4-methylthiazol-5-yl}propenone 
• 6685-76-3 phenylguanidinium hydrogencarbonate 
• 123-54-6 acetylacetone 
• 1694-29-7 3-chloropentane-2,4-dione 
• 62-53-3 aniline 

Relevant articles and documents

Synthesis of novel thiazolyl-pyrimidines and their anticancer activity in vitro

A series of novel compounds 7-43 were prepared via the condensation of enaminones 4a-h and the guanidines carbonate 6a-f. The structures of these newly synthesized compounds were confirmed by 1H-NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL-7404, SPC-A-01 and SGC-7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549. Thiazolyl-pyrimidines were synthesized by the general pyrimidine condensation of Bredereck and their in-vitro anticancer activities were evaluated. Copyright