700358-67-4Relevant academic research and scientific papers
The first case of diastereoselective cycloadditions of enantiopure nitrilimines in aqueous media
Molteni, Giorgio
, p. 1077 - 1079 (2004)
The diastereoselective cycloadditions of enantiopure nitrilimines 4 with ethyl acrylate were exploited in dry toluene and in aqueous sodium hydrogencarbonate as reaction media. Shorter reaction times and improved diastereoisomeric ratios of the resulting 5-ethoxycarbonyl-4,5-dihydropyrazoles 5 and 6 were observed in aqueous media.
