700381-18-6

Usage

Uses

Used in Organic Synthesis:
5-Fluoro-2-methoxybenzyl bromide 97 is used as a reagent in organic synthesis for its ability to introduce the 5-fluoro-2-methoxybenzyl group into different compounds. This property makes it valuable in the creation of new chemical entities with specific functional groups, which can be utilized in various applications across different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Fluoro-2-methoxybenzyl bromide 97 is used as an intermediate in the synthesis of various drug molecules. Its ability to introduce the 5-fluoro-2-methoxybenzyl group can contribute to the development of new pharmaceutical compounds with improved therapeutic properties.
Used in Chemical Research:
5-Fluoro-2-methoxybenzyl bromide 97 is also used in chemical research as a tool to study the reactivity and properties of the 5-fluoro-2-methoxybenzyl group. Researchers can use 5-FLUORO-2-METHOXYBENZYL BROMIDE 97 to explore its potential applications and understand the mechanisms of reactions involving this functional group.
Used in Material Science:
In material science, 5-Fluoro-2-methoxybenzyl bromide 97 can be used as a precursor to develop new materials with specific properties. The introduction of the 5-fluoro-2-methoxybenzyl group can lead to the creation of materials with unique characteristics, such as improved stability, reactivity, or selectivity, which can be applied in various technological applications.

InChI:InChI:1S/C8H8BrFO/c1-11-8-3-2-7(10)4-6(8)5-9/h2-4H,5H2,1H3

Upstream product

• 426831-32-5 (5-fluoro-2-methoxyphenyl)methanol 
• 399-54-2 4-fluoro-2-methylanisole 
• 19415-51-1 5-fluoro-2-methoxybenzaldehyde 

Downstream Products

• 1195425-74-1 (R)-2-[5-fluoro-2-(methyloxy)phenyl]-1-[(S)-4-(phenylmethyl)morpholin-2-yl]-1-(tetrahydro-2H-pyran-4-yl)ethanol 
• 709025-81-0 2-hydroxy-5-fluorophenyl-acetonitrile 
• 1260902-19-9 C₇H₆BrFO 
• 1292306-50-3 C₁₅H₁₂FNO 
• 1539309-79-9 {(S)-1-[(S)-1-(5-fluoro-2-methoxy-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3yl carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester 
• 501008-41-9 2-(5-fluoro-2-methoxyphenyl)acetonitrile 
• 78550-50-2 5,5'-difluoro-2,2'-dihydroxy-diphenyl-methane 
• 1403980-17-5 C₉H₆FIO 
• 948850-56-4 5-fluoro-2-methoxybenzylzinc bromide 

Relevant academic research and scientific papers

Synthesis of Phenanthridines through Palladium-Catalyzed Cascade Reaction of 2-Halo-N-Ms-arylamines with Benzyl Halides/Sulfonates

An efficient palladium-catalyzed nucleophilic substitution/C–H activation/aromatization cascade reaction between readily available 2-halo-N-Ms-arylamines (Ms = methanesulfonyl) and benzyl halides/sulfonates has been described. A wide variety of phenanthridines were synthesized in a one-pot fashion in moderate to high yields (37–86 %). Notably, this method provides a straightforward, facile approach for the synthesis of phenanthridines. The practicality was further substantiated by successfully carrying out a gram-scale preparation.

SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF

The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.

NITROGENATED FUSED RING DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE OF THE SAME FOR MEDICAL PURPOSES

[Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. [Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; RA and RB are independently halogen, cyano, alkyl, alkylsulfonyl, -OW1, -SW1, -COW2, -NW3W4, -SO2NW3W4, aryl, etc.; RC is H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, -CO-Y, -SO2-Y -S-(alkylene)-Y, -O-(alkylene)-Y, -SO2-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.

ORGANIC COMPOUNDS

A compound of formula (I); in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, m, n, w, X, Y and Q have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 receptor, especially inflammatory or obstructive airways diseases.

MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS

Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.