70044-38-1Relevant academic research and scientific papers
Transformations of anilides of 3-aryl-2,3-epoxypropionic acids when exposed to acidic agents
Mamedov,Mamedova,Khikmatova,Samigullina,Gubaidullin,Bazanova,Rizvanov, I. Kh.,Sinyashin
, p. 2857 - 2864 (2015)
Anilides of 3-aryl-2,3-epoxypropionic acids on treatment with aqueous HBr gave 3-aryl-3-bromo-2-hydroxypropionic acid anilides and (in some cases) 2-bromo-3-hydroxy regioisomers. Cyclization of these products into 3-arylquinolin-2(1H)-ones was studied.
A highly enantioselective Darzens reaction between diazoacetamides and aldehydes catalyzed by a (+)-pinanediol-Ti(OiPr)4 system
Liu, Gang,Zhang, Daming,Li, Jian,Xu, Guangyang,Sun, Jiangtao
supporting information, p. 900 - 904 (2013/02/25)
A highly efficient enantioselective Darzens reaction of aldehydes with diazoacetamides catalyzed by a (+)-pinanediol-Ti(OiPr)4 system has been developed. The cis-glycidic amides were obtained in high yields and with moderate to excellent enantioselectivity (up to 99%).
Dynamic ligand exchange of the lanthanide complex leading to structural and functional transformation: One-pot sequential catalytic asymmetric epoxidation-regioselective epoxide-opening process
Tosaki, Shin-Ya,Tsuji, Riichiro,Ohshima, Takashi,Shibasaki, Masakatsu
, p. 2147 - 2155 (2007/10/03)
The characteristic property of the lanthanide complex, which easily undergoes a dynamic ligand exchange and alters its structure and function in situ, is described. After the completion of the catalytic asymmetric epoxidation of various α,β-unsaturated amides 2 in the presence of the Sm-(S)-BINOL-Ph3-As=O (1:1:1) complex 1 (2-10 mol %), the addition of Me3SiN3 directly to the reaction mixture led to smooth epoxide-opening at room temperature, affording the corresponding anti-β-azido-α-hydroxyamide 4 in excellent overall yield (up to 99%) with complete regioselectivity and excellent enantiomeric excess (up to >99%). The key to the success of the sequential process was the in situ generation of the highly reactive samarium azide complex through dynamic ligand exchange. In situ IR spectroscopy and other experiments provided strong evidence that the samarium azide complex was generated. In addition, the relatively high Lewis basicity of the amide moiety had a key role in the high reactivity of both the epoxidation and the epoxide-opening reactions. Examinations of other nucleophiles such as sulfur or carbon nucleophiles as well as transformations of epoxide-opened products are also described.
Polyaniline supported cobalt(II) catalyst: Oxidation of alkenes with molecular oxygen
Das, Bhaskar C,Iqbal, Javed
, p. 1235 - 1238 (2007/10/03)
Polyaniline supported Co(II) acetate catalyses the oxidation of different alkenes in the presence of 2-methylpropanol under the oxygen atmosphere at ambient temperature. This catalyst can be reused for epoxidations without any decline in its catalytic efficiency.
Polyaniline supported cobalt(II)-salen catalyst: One pot synthesis of B-phenylisoserine derivaties from cinnamoyl amide
Das, Bhaskar C.,Iqbal, Javed
, p. 2903 - 2906 (2007/10/03)
A novel one pot conversion of cinnamoyl amides to the corresponding phenylisoserine derivatives war developed by employing polyaniline supported cobalt(II)-salen catalysed/formation of the epoxide followed by its opening with anilines at ambient condition
