70057-75-9Relevant articles and documents
A novel class of ion displacement ligands as antagonists of the αiIbβ3 receptor that limit conformational reorganization of the receptor
Jiang, Jian-Kang,McCoy, Joshua G.,Shen, Min,LeClair, Christopher A.,Huang, Wenwei,Negri, Ana,Li, Jihong,Blue, Robert,Harrington, Amanda Weil,Naini, Sarasija,David III, George,Choi, Won-Seok,Volpi, Elisabetta,Fernandez, Joseph,Babayeva, Mariana,Nedelman, Mark A.,Filizola, Marta,Coller, Barry S.,Thomas, Craig J.
supporting information, p. 1148 - 1153 (2014/03/21)
A collection of αIIbβ3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents' structure-activity relationships, binding modality, and pharmacokinetic and pharmacodynamic