70058-19-4

Usage

Uses

Used in Pharmaceutical Industry:
Zaltoprofen is utilized as an analgesic and anti-inflammatory agent for the treatment of conditions such as osteoarthritis and rheumatoid arthritis. Its application is based on its capacity to mitigate pain and inflammation, providing relief to patients suffering from these diseases.
Used in Medical Treatments:
As a nonsteroidal anti-inflammatory drug, Zaltoprofen is used in the management of other inflammatory diseases where reducing inflammation and alleviating pain are critical for patient comfort and disease management.

Upstream product

• 85-44-9 phthalic anhydride 
• 2749-11-3 (S)-Alaninol 
• 6168-72-5 2-Amino-1-propanol 

Downstream Products

• 321936-54-3 (+)-(S)-2-[2-(4-chloro-2,6-dimethylphenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione 
• 171557-25-8 (S)-N-(2-phthalimido-1-propyl)-N-(p-toluenesulfonyl)glycine tert-butyl ester 
• 171557-26-9 [[(S)-2-(2-Hydrazinocarbonyl-benzoylamino)-propyl]-(toluene-4-sulfonyl)-amino]-acetic acid tert-butyl ester 
• 934987-50-5 2-((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)-1H-isoindole-1,3(2H)-dione 
• 1252084-91-5 (-)-(S)-2-[2-(3-methoxyphenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione 
• 1152595-80-6 2-({[(1S)-1-methyl-2-({[(4-methylphenyl)amino]carbonothioyl}oxy)ethyl]amino}carbonyl)benzoic acid 
• 1152595-84-0 2-({[(1S)-2-({[(4-chlorophenyl)amino]carbonothioyl}oxy)-1-methylethyl]amino}carbonyl)benzoic acid 
• 1152595-44-2 O-[(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl] 4-chlorophenylthiocarbamate 
• 1035342-78-9 2-[(2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]isoindol-1,3-dione 
• 501121-59-1 2-(2-fluoro-1-methyl-2-(phenylsulfanyl)ethyl)isoindole-1,3-dione 

Relevant academic research and scientific papers

Ester Formation via Nickel-Catalyzed Reductive Coupling of Alkyl Halides with Chloroformates

The synthesis of alkyl esters from readily available alkyl halides and chloroformates was achieved for the first time using a mild Ni-catalyzed reductive coupling protocol. Unactivated primary and secondary alkyl iodides as well as glycosyl, benzyl, and aminomethyl halides were successfully employed to yield products in moderate to excellent yields with high functional group tolerance.

BRANCHED CHAIN ALKYL HETEROAROMATIC RING DERIVATIVE

A branched chain alkyl heteroaromatic ring derivative represented by formula (Ia) or a pharmaceutically acceptable salt thereof is useful for treatment or prophylaxis of diseases such as sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease, Parkinson's disease, Huntington's disease, eating disorder, cephalalgia, hemicrania, pain, digestive diseases, epilepsy, inflammation, immune-related diseases, endocrine-related diseases and hypertension, on the basis of the orexin (OX) receptor antagonist activity.

Searching for new antiarrhythmic agents: Evaluation of meta- hydroxymexiletine enantiomers

Mexiletine is a very well-known class IB antiarrhythmic drug, whose enantiomers differ in both pharmacodynamic and pharmacokinetic properties, the (R)-isomer being the eutomer on experimental arrhythmias and in binding studies on cardiac voltage-gated sodium channels. meta-Hydroxymexiletine (MHM) is a minor metabolite of mexiletine, which has demonstrated to be more potent than the parent compound. Herein we report the synthesis and biological evaluation of MHM enantiomers for their potential antiarrhythmic activity. The same stereoselectivity pattern observed for mexiletine was found for MHM: the (R)-enantiomer of MHM was the eutomer on ac-arrhythmia also showing a negative inotropism higher than the one displayed by mexiletine and, at the same time, a decreased vasorelaxant activity on guinea-pig left atrium and guinea-pig ileum longitudinal smooth muscle.

OXAZOLO [5, 4 -B] PYRIDIN- 5 -YL COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention provides oxazolo[5,4-b]pyridin-5-yl compounds useful in the treatment of cancer.

Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors

A series of phenoxyalkyl and phenylthioalkyl amides were prepared as melatoninergic ligands. Modulation of affinity of the newly synthesized compound by applying SARs around the terminal amide moiety, the alkyl chain, and the methoxy group on the aromatic ring provides compounds with nanomolar affinity for both melatonin receptor subtypes. Affinity towards MT1 and MT2 receptors were modulated also exploiting chirality. The investigation of intrinsic activity revealed that all the tested compounds behave as full or partial agonists.

Novel modifications in the series of O-(2-phthalimidoethyl)-N-substituted thiocarbamates and their ring-opened congeners as non-nucleoside HIV-1 reverse transcriptase inhibitors

The structure-activity relationships (SARs) of N-aryl-O-(2-phthalimidoethyl)thiocarbamates (C-TCs) and their imide ring-opened congeners (O-TCs) as non-nucleoside HIV-1 reverse transcriptase inhibitors were further investigated. The SAR strategy involved

SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS

Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS

Compounds of formula (I): [Chemical formula should be inserted here. Please see paper copy] or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal)

NOVEL BICYCLIC SULFONAMIDES FOR USE AS GLUCOCORTICOID RECEPTOR MODULATORS IN THE TREATMENT OF INFLAMMATORY DISEASES

Compounds of formula (I): or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).

A new approach towards peptidosulfonamides: synthesis of potential inhibitors of bacterial peptidoglycan biosynthesis enzymes MurD and MurE

Peptidosulfonamides are an emerging group of peptidomimetics with a variety of applications in medicinal chemistry. We present a novel approach to the synthesis of peptidosulfonamides, and apply it to a series of new potential inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurE. The synthesis was conducted via N-phthalimido β-aminoethanesulfonyl chlorides, which are new building blocks for the synthesis of peptidosulfonamides. In the most crucial step, sulfonic acids or their sodium salts were converted into the corresponding sulfonyl chlorides using an excess of either SOCl2 or SOCl2/DMF, and then coupled to the C-protected amino acid. None of the compounds significantly inhibited MurD, however, some inhibited MurE; one had an IC50 below 200 μM, which constitutes a promising starting point for further development. Molecular modelling simulations were performed on two analogues to investigate the absence of inhibitory activity of the sulfonamide compounds on MurD.