7007-32-1

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 100-73-2 acrolein dimer 
• 3749-36-8 2-hydroxymethyl-3,4-dihydro-2H-pyran 
• 16698-52-5 3,4-dihydro-2H-pyran-2-carboxylic acid sodium salt 

Downstream Products

• 287176-45-8 [phenyl-⁽²⁾H₅]-2-Benzyl-3,4-dihydro-2H-pyran 
• 287176-40-3 2-Benzyl-3,4-dihydro-2H-pyran 
• 83580-49-8 2-(4-chlorobenzyloxymethyl)-3,4-dihydro-2H-pyran 

Relevant academic research and scientific papers

Ultrafast Photoclick Reaction for Selective18F-Positron Emission Tomography Tracer Synthesis in Flow

The development of very fast, clean, and selective methods for indirect labeling in PET tracer synthesis is an ongoing challenge. Here we present the development of an ultrafast photoclick method for the synthesis of short-lived18F-PET tracers

Catechols as Sources of Hydrogen Atoms in Radical Deiodination and Related Reactions

When used with trialkylboranes, catechol derivatives, which are low-cost and low toxicity, are valuable hydrogen atom donors for radical chain reactions involving alkyl iodides and related radical precursors. The system 4-tert-butylcatechol/triethylborane has been used to reduce a series of secondary and tertiary iodides, a xanthate, and a thiohydroxamate ester. Catechol derivatives are right in the optimal kinetic window for synthetic applications, as demonstrated by highly efficient radical cyclizations. Cyclizations leading to the formation of quaternary centers can be performed in an all-at-once process (no slow addition of the hydrogen atom donor) at standard concentrations. The H-donor properties of catechol derivatives can be fine-tuned by changing their substitution pattern. In slow radical cyclization processes, an enhanced ratio of cyclized/uncyclized products was obtained by using 3-methoxycatechol instead of 4-tert-butylcatechol.

BIPHENYL COMPOUNDS AND USES THEREOF

The present invention relates to biphenyl compounds and uses thereof in medicine. Specifically, the present invention relates to a compound of Formula (I), or a stereoisomer, a geometric isomer, a tautomer, a mesomer, a racemate, an enantiomer, a diastereoisomer, an N-oxide, a hydrate, a solvate, a metabolite, a hydrolysate, a pharmaceutically acceptable salt or a prodrug thereof. The compound disclosed herein is used as a therapeutic agent particularly a GPR40 agonist for treating diabetes and metabolic disease in a patient.

Oxygen to carbon rearrangements of anomerically linked alkenols from tetrahydropyran derivatives: An investigation of the reaction mechanism via a double isotopic labelling crossover study

A variety of alkenol tetrahydropyran derivatives were prepared and subjected to a tin tetrachloride promoted anomeric oxygen to carbon rearrangement. Using this methodology many of the corresponding carbon-linked structures were synthesised, including alkenes and bicyclic ethers, in good yields. On the basis of an isotopic labelling study using 2H incorporated into the side chain and ring system it is proposed that these reactions proceed via an intermodular pathway. The Royal Society of Chemistry 2000.

On the Mechanism of Organoaluminum-Promoted Claisen Rearrangement of Allylic Vinyl Ethers

The organoaluminum-promoted Claisen rearrangement of allylic vinyl ethers has been mechanistically studied by two sets of experiments and the observed Z and E selectivity is best accounted for by two possible chair-like structures with R substituents axial and equatorial, respectively.

Anti-microbial diazole derivatives

Compounds of formula (I): STR1 [wherein: Q represents a =CH-- group or a nitrogen atom; R1 represents a methylene group, a group of formula (R3 being a substituted or unsubstituted phenyl group) or a group of formula (n being 1 or 2 and R4 being a substituted or unsubstituted phenyl or phenylalkyl group); and A represents a group of formula (R2 being an alkenyl group, an alkynyl group or a substituted or unsubstituted alkyl or phenyl group) or a group of formula (X being an oxygen or sulphur atom and R11 being an aryl or aralkyl group or, when X represents an oxygen atom, R11 being a hydrogen atom or a carbonyloxy or sulphonyloxy group) and acid addition salts and metal complexes thereof are valuable antimicrobial agents having low toxicity to humans and other animals and are especially valuable for the eradication of fungi.

INFLUENCE DU GROUPEMENT METHOXYLE EN C-1 DANS L'ORIENTATION DE LA REDUCTION DES METHYL-HEXOPYRANOSID-2-ULOSES PAR LE BOROHYDRURE DE SODIUM

Methyl 3,4-dideoxy- and -3,4,6-trideoxyhexopyranosiduloses were synthesized by two reaction pathways.The α anomers were stereoselectively reduced by sodium borohydride to give compounds having the α-erythro configuration.Under the same conditions, the β a