70071-36-2

Upstream product

• 70071-32-8 r-2,cis-6-bis(p-chlorophenyl)-4-thianone oxime 
• 78870-89-0 Toluene-4-sulfonic acid (2S,4R,6R)-2,6-bis-(4-chloro-phenyl)-tetrahydro-thiopyran-4-yl ester 
• 27798-82-9 r-2,cis-6-bis(p-chlorophenyl)-4-thianone 
• 32428-31-2 trans-2-trans-6-Di-p-chlorphenyltetrahydrothiapyran-4-ol 

Downstream Products

• 85404-44-0 [(2R,4S,6S)-2,6-Bis-(4-chloro-phenyl)-tetrahydro-thiopyran-4-yl]-dimethyl-amine 
• 78918-43-1 [(2R,4S,6S)-Bis-(4-chloro-phenyl)-tetrahydro-thiopyran-4-yl]-(2,4-dinitro-phenyl)-amine 

Relevant academic research and scientific papers

Synthesis and Conformational Analysis of Substituted 4-Aminothianes

Reductions of substituted 4-thianone oximes by LiAlH4 gave a mixture of epimeric 4-aminothianes.Separation of the epimeric mixture was achieved via column chromatography over neutral alumina.Independent syntheses of these amines by a stereospecific route starting from the tosylate of the corresponding 4-thianols that reacted with sodium azide in DMF followed by reduction of the azide with LiAlH4 provided structure proofs for the amines.N-Acetyl derivatives were also prepared from the aminothianes.Conformational analysis of the amines was performed via an inspection of the (1)H and (13)C NMR spectra.These spectral data suggested t wist conformations for 2,2-dimethyl-trans-6-phenyl-r-4-aminothiane and 2,2-dimethyl-trans-6-p-chlorophenyl-r-4-aminothiane.