700832-79-7

Upstream product

• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 700832-80-0 1-{4-[1-Ethyl-1-(4-iodophenyl)-propyl]}-2-methyl-phenol 
• 1292827-38-3 (5R)-N-[1-(4-acetylphenyl)-1-ethylpropyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1292828-08-0 C₃₀H₃₉N₅O₃ 
• 667931-65-9 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoic acid 
• 683745-75-7 ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate 
• 683203-70-5 (5R)-N-[1-ethyl-1-(4-iodophenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1292828-04-6 3-(4-iodophenyl)pentan-3-amine hydrochloride 
• 1292904-34-7 (5R)-N-{1-ethyl-1-[4-(1-hydroxyethyl)phenyl]propyl}-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 

Relevant academic research and scientific papers

Novel and potent calcium-sensing receptor antagonists: Discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6, 7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent

The calcium-sensing receptor antagonist (CaSR) has been recognized as a promising target of anabolic agents for treating osteoporosis. In the course of developing a new drug candidate for osteoporosis, we found tetrahydropyrazolopyrimidine derivative 1 to

Vesicant treatment with phenyl-phenyl type vitamin d receptor modulators

The present invention relates to a method of treating or preventing damage to human skin cells by chemical vesicants by administering a non-secosteroidal, diphenyl compound with vitamin D receptor (VDR) modulating activity.

VITAMIN D RECEPTOR MODULATORS

The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1a,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.