667931-65-9

Upstream product

• 667920-89-0 ethyl 2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 1293345-01-3 ethyl (5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 667930-86-1 (5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid 
• 700832-79-7 3-(4-iodophenyl)pentan-3-ol 
• 1292828-04-6 3-(4-iodophenyl)pentan-3-amine hydrochloride 
• 683203-70-5 (5R)-N-[1-ethyl-1-(4-iodophenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 683745-75-7 ethyl 4-[1-ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)propyl]benzoate 
• 1207507-51-4 C₁₈H₂₁N₃O₂ 
• 5650-07-7 3-methyl-1-phenyl-but-2-en-1-one 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 23286-70-6 5-amino-3-methyl-1H-pyrazole-4-carboxylic acid ethyl ester 

Downstream Products

• 1292904-34-7 (5R)-N-{1-ethyl-1-[4-(1-hydroxyethyl)phenyl]propyl}-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1292827-38-3 (5R)-N-[1-(4-acetylphenyl)-1-ethylpropyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1292828-08-0 C₃₀H₃₉N₅O₃ 

Relevant academic research and scientific papers

Substituted pyrazolo[1,5-A] pyrimidines as calcium receptor modulating agents

There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7-membered ring; ring B is an optionally substituted 5- to 7-membered heterocyclic ring; X1 is CR1/

Novel and potent calcium-sensing receptor antagonists: Discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6, 7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent

The calcium-sensing receptor antagonist (CaSR) has been recognized as a promising target of anabolic agents for treating osteoporosis. In the course of developing a new drug candidate for osteoporosis, we found tetrahydropyrazolopyrimidine derivative 1 to