700875-86-1Relevant academic research and scientific papers
A chiral amino-naphthalene-derived prolinamide catalyst for the enantioselective Michael addition of ketones to nitroolefins
Yu, Chuanming,Zhang, Ke,Shi, Xiangjun
, p. 278 - 282 (2012/09/25)
An enantioselective Michael addition of ketones to nitroolefins has been accomplished using a novel chiral aminonaphthalenederived prolinamides catalyst 1. The desired Michael adducts were obtained in high yields (up to 93%) as well as good diastereoselectivities (>99:1) and enantioselectivities (48%-99% ee).
Preparation of pyrrolidine-oxazoline containing ligands and their application in asymmetric transfer hydrogenation
McManus, Helen A.,Barry, Sarah M.,Andersson, Pher G.,Guiry, Patrick J.
, p. 3405 - 3416 (2007/10/03)
Nine members of a new ligand class incorporating both an oxazoline ring and a pyrrolidine unit were prepared in an efficient four-step synthesis starting from readily available chiral amino alcohols and proline. A study of these ligands in the asymmetric transfer hydrogenation of acetophenone showed that the catalysts formed from [Ir(cod)Cl]2 were the most active while those derived from [Ru(p-cymene)Cl2]2 gave the highest enantioselectivities (up to 61% ee).
