70093-12-8

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C15H10FNO/c16-11-7-5-10(6-8-11)15-13(9-18)12-3-1-2-4-14(12)17-15/h1-9,17H

Upstream product

• 1994-40-7 1-(1-(4-fluorophenyl)ethylidene)-2-phenylhydrazine 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 782-17-2 2-(4-fluorophenyl)indole 

Downstream Products

• 131520-49-5 5-<2-(4-fluorophenyl)-1H-indol-3-ylmethylene>-2,4,6(1H,3H,5H)-pyrimidinetrione 
• 70093-14-0 butyl-[2-(4-fluoro-phenyl)-indol-3-ylmethylene]-amine 
• 109272-04-0 2-{[1-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-pentafluorophenyl-meth-(E)-ylidene]-thiazolidin-4-one 
• 109272-01-7 2-{[1-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-thiazolidin-4-one 
• 109272-00-6 2-{[1-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-(2-nitro-phenyl)-meth-(E)-ylidene]-thiazolidin-4-one 
• 109272-05-1 5-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-2-{[1-[2-(4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-thiazolidin-4-one 
• 109271-98-9 5-[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-2-{[1-[2-(4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-thiazolidin-4-one 
• 109272-02-8 2-{[1-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-(2-fluoro-phenyl)-meth-(E)-ylidene]-thiazolidin-4-one 
• 109271-99-0 5-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-2-{[1-[2-(4-fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-thiazolidin-4-one 
• 109272-03-9 2-{[1-[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-meth-(Z)-ylidene]-hydrazono}-5-[1-(4-fluoro-phenyl)-meth-(E)-ylidene]-thiazolidin-4-one 
• 109271-93-4 C₁₆H₁₃FN₄S 

Relevant academic research and scientific papers

Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase

The design and synthesis of novel multi-substituted benzo-indole pyrazole Schiff base derivatives of potent DNA gyrase inhibitory activity were the main aims of this study. All the novel synthesized compounds were examined for their antibacterial activities against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella. In addition, we selected 20 compounds for the in vitro antibacterial activities assay of 6 drug-resistant bacteria strains. The result revealed compound 8I-w exhibited excellent antibacterial activity against 4 drug-resistant E. coli bacteria strains with IC50 values of 7.0, 17.0, 13.5, and 1.0 μM, respectively. In vitro enzyme inhibitory assay showed that compound 8I-w displayed potent inhibition against DNA gyrase with IC50 values of 0.10 μM. The molecular docking model indicated that compounds 8I-w can bind well to the DNA gyrase by interacting with various amino acid residues. This study demonstrated that the compound 8I-w can act as the most potent DNA gyrase inhibitor in the reported series of compounds and provide valuable information for the commercial DNA gyrase inhibiting bactericides.

Green approach for the synthesis of 3-methyl-1-phenyl-4-((2-phenyl-1H-indol 3-yl)methylene)-1H-pyrazole-5(4H)-ones and their DNA Cleavage, antioxidant, and antimicrobial activities

3-Methyl-1-phenyl-4-((2-phenyl-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-ones (5a-i) was prepared by the condensation reaction of different 3-formyl-2-phenylindole derivatives (2a-i) and 3-methyl-1-phenyl-2-pyrazoline-5-one in quantitative yield by applying various green synthetic methods as grinding, microwave irradiation using different catalysts under solvent-free mild reaction conditions with high product yields. The structures of the synthesized compounds were characterized on the basis of elemental analysis, infrared, 1HNMR, 13C NMR, and mass spectral data. The synthesized compounds were screened for free radical scavenging, antimicrobial, and DNA cleavage activities. Most of the tested compounds belonging to the 3-methyl-1-phenyl-4-((2-phenyl-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-ones series exhibited promising activities.

Microwave-Assisted synthesis of 30-indolyl substituted 4H-chromenes catalyzed by DMAP and their antimicrobial activity

A new series of indole-based chromene derivatives 4a-4p has been synthesized by one pot cyclocondensation reaction of 2-phenyl-1H-indole-3- carbaldehyde 1a-1h; malononitrile 2; and 1,3-cyclohexanedione/dimedone 3a/b under microwave irradiation catalyzed by an organocatalyst 4-(N,N-dimethylamino) pyridine. Easy experimental procedure, high yield, selectivity, and shorter reaction time are the imperative features of this method. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than that of standard drugs as evident from SAR study. Springer Science+Business Media, LLC 2011.

2-Indolyl Imidazo [4,5-d] Phenanthroline Derivatives and Their Use in the Treatment for Cancer

2-indolyl imidazo[4,5-d]phenanthroline compounds of Formula I that are capable of intracellular chelation of transition metals and of exerting antiproliferative effects in cancer cells, that are cytostatic and/or cytotoxic, are provided. Compounds of Form