701-38-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Fluorophenyl)propan-1-ol is used as an intermediate in the synthesis of various pharmaceutical compounds due to its unique chemical structure and reactivity. Its presence in the manufacturing process can contribute to the development of new drugs with improved efficacy and safety profiles.
Used in Fragrance Industry:
As a building block in the creation of fragrance compounds, 1-(3-Fluorophenyl)propan-1-ol is used for its sweet and floral odor, enhancing the sensory experience of various consumer products such as perfumes, cosmetics, and personal care items.
Used in Medicinal Chemistry Research:
1-(3-Fluorophenyl)propan-1-ol is utilized in research for its psychoactive properties, acting as a stimulant. This makes it a candidate for investigation in the field of medicinal chemistry, where it may contribute to the development of new therapeutic agents for the treatment of various conditions.
Used in Recreational Drug or Research Chemical Context:
Although not approved for medical use in most countries, 1-(3-Fluorophenyl)propan-1-ol is known for its potential use as a recreational drug or research chemical. Its psychoactive properties may have implications for further study and understanding of its effects on the human body and mind. However, it is important to note the potential risks and legal restrictions associated with its use in this context.

InChI:InChI=1/C9H11FO/c1-2-9(11)7-4-3-5-8(10)6-7/h3-6,9,11H,2H2,1H3

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 456-48-4 3-Fluorobenzaldehyde 
• 74-96-4 ethyl bromide 
• 455-67-4 1-(3-fluorophenyl)propan-1-one 
• 1073-06-9 3-fluorobromobenzene 
• 123-38-6 propionaldehyde 

Downstream Products

• 455-67-4 1-(3-fluorophenyl)propan-1-one 
• 172748-78-6 (R)-1-(3-fluoro-phenyl)-propan-1-ol 
• 172748-78-6 (S)-1-(3'-fluorophenyl)propan-1-ol 
• 38340-11-3 1-fluoro-3-(1-propen-1-yl)benzene 
• 28593-12-6 1-(3-fluorophenyl)propane 
• 321939-65-5 2-fluoro-1-iodo-4-propylbenzene 
• 442661-38-3 4-n-propyl-2-fluorophenylboronic acid 
• 92821-83-5 2-bromo-1-(3-fluorophenyl)propan-1-one 

Relevant academic research and scientific papers

Efficient Transfer Hydrogenation of Ketones using Methanol as Liquid Organic Hydrogen Carrier

Herein, we demonstrate an efficient protocol for transfer hydrogenation of ketones using methanol as practical and useful liquid organic hydrogen carrier (LOHC) under Ir(III) catalysis. Various ketones, including electron-rich/electron-poor aromatic ketones, heteroaromatic and aliphatic ketones, have been efficiently reduced into their corresponding alcohols. Chemoselective reduction of ketones was established in the presence of various other reducible functional groups under mild conditions.

NBS-mediated synthesis of β-keto sulfones from benzyl alcohols and sodium arenesulfinates

An efficient synthetic route towards the synthesis of β-keto sulfones has been developed from secondary benzyl alcohols using N-bromosuccinimide (NBS). The present protocol utilizes NBS as oxidant as well as brominating agent, readily accessible benzyl alcohols and sodium arenesulfinates as the sulfonylating reagent under mild conditions. The control experiments revealed that the reaction proceeds via oxidation of alcohol to ketone, α-bromination of ketone and nucleophilic substitution by sodium arenesulfinate. Furthermore, the efficiency of the methodology was tested with a gram scale reaction and also shown the synthetic utility.

Halogen-bonded iodonium ion catalysis: A route to α-hydroxy ketones: Via domino oxidations of secondary alcohols and aliphatic C-H bonds with high selectivity and control

A domino synthesis of α-hydroxy ketones has been developed from benzylic secondary alcohols employing catalytic iodonium ions stabilized by DMSO. The reaction proceeds through an unprecedented sequential oxidation of alcohols to ketone and its α-hydroxylation in a controlled manner. The spectroscopic evidence establishes the possibility of formation of a stable halogen-bonded adduct between DMSO and iodonium ions.

Synthesis and mesomorphic properties of laterally fluorinated alkyl 4′′-alkylterphenyl-4-yl carbonate liquid crystals

Fifteen series of homologues of a variety of mono-, di- and trifluorosubstituted alkyl 4′′-alkylterphenyl-4-yl carbonates have been synthesized and their mesomorphic properties have been determined. From among 95 prepared compounds, 40 pure nematogens have been found, as well as 55 mesogens with orthogonal and tilted smectic phases in broad temperature ranges. The type and combination of the LC phase strongly depend on the position and number of the fluorine atoms. Physical properties and correlations between the molecular core fluorosubstitution, the length of the terminal chains and the type and sequence of the liquid crystalline phases, have been determined. The compounds are useful for the formulation of nematic mixtures as well as ferroelectric ones.

Liquid crystal carbonate and liquid crystal medium containing the same with positive or negative dielectric anisotropy

A novel liquid crystalline carbonate and the mixture containing the same: wherein R3 is an alkyl (H2n+1Cn) or an alkenyl (H2n?1Cn) group, each of 1 to 12 carbon atoms, the ring A is laterally unsubstituted benze

Alternative method for alkylation of arylpolyhalomethanes with trialkylborane in the presence of magnesium

Reduction of benzal halide derivatives and α,α,α,-trichloromethylbenzene by magnesium powder in DMAc affords α-halocarbanions which then react with triethylborane to give alkylated products. After oxidation with H2O2-NaOH, secondary

Method of Synthesizing Key Intermediates for the Production of Camptothecin Derivatives

The present invention discloses a process for efficient production of 2-amino-5-hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skeleton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.

METHOD OF SYNTHESIZING KEY INTERMEDIATES FOR THE PRODUCTION OF CAMPTOTHECIN DERIVATIVES

The present invention discloses a process for efficient production of 2-amino-5- hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skelton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.

Synthesis and activity of 2-methyl-3-aminopropiophenones as centrally acting muscle relaxants

Some novel 2-methyl-3-aminopropiophenones were synthesized and their centrally acting muscle relaxant activities were,evaluated for an inhibitory effect on the flexor reflex in rats. The structure-activity relationships are discussed. In this series 2-methyl-3-pyrrolidino-1-(4-trifluoromethylphenyl)-propan-1-one (28) showed significant centrally acting muscle relaxant activity. In addition, the activities of each enantiomer (28-(S) and (R)) were studied along with their acute toxicities. Compound 28-(R) was found to exhibit more potent activity and weaker acute toxicity than 28-(S). Accordingly, compound 28-(R) (NK433) is under development as a novel centrally acting muscle relaxant.