92821-83-5

Basic information

• Product Name: 2-bromo-3-fluoropropiophenone
• Synonyms: 2-bromo-3-fluoropropiophenone
• CAS NO: 92821-83-5
• Molecular Formula: C₉H₈BrFO
• Molecular Weight: 231.0616232
• Mol File: 92821-83-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 255 °C at 760 mmHg
• Flash Point: 108 °C
• Appearance: /
• Density: 1.488 g/cm³
• Vapor Pressure: 0.0168mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 2-bromo-3-fluoropropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-3-fluoropropiophenone(92821-83-5)
• EPA Substance Registry System: 2-bromo-3-fluoropropiophenone(92821-83-5)

Safety Data

• Hazardous Substances Data: 92821-83-5(Hazardous Substances Data)

Usage

General Description

2-bromo-3-fluoropropiophenone is a chemical compound with the molecular formula C9H8BrFO. It is a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2-bromo-3-fluoropropiophenone is known for its use in the production of mixed halogenated aromatic compounds, which have important applications in the pharmaceutical and agricultural industries. It is also used as a building block in the synthesis of complex organic molecules. However, it is important to handle 2-bromo-3-fluoropropiophenone with caution, as it is a hazardous chemical that can cause irritation to the skin, eyes, and respiratory system. Proper safety precautions should be taken when working with this compound.

InChI:InChI=1/C9H8BrFO/c1-6(10)9(12)7-3-2-4-8(11)5-7/h2-6H,1H3

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 701-38-2 1-(3-fluorophenyl)propan-1-ol 
• 455-67-4 1-(3-fluorophenyl)propan-1-one 
• 462-06-6 fluorobenzene 

Downstream Products

• 34841-40-2 2-tert-butylamino-3'-fluoropropiophenone 
• 1394204-85-3 2-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(3-fluorophenyl)propan-1-one 
• 1394148-26-5 2-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(3-fluorophenyl)propan-1-one hydrochloride 
• 1384067-13-3 4-(3-fluorophenyl)-5-methyloxazol-2(3H)-one 
• 1188043-08-4 2-chloro-4-(3-fluorophenyl)-5-methylthiazole 
• 1384067-11-1 2-chloro-4-(3-fluorophenyl)-5-methyloxazole 
• 1384067-23-5 1-(3-fluorophenyl)-2-thiocyanatopropan-1-one 
• 1350768-21-6 2-(3-fluoro-phenyl)-3-methyl-morpholin-2-ol 
• 1214939-94-2 2-(N-cyclopentylamino)-3'-fluoropropiophenone 
• 1214939-99-7 2-(N-pyrrolidinyl)-3'-fluoropropiophenone 

Relevant articles and documents

NBS-mediated synthesis of β-keto sulfones from benzyl alcohols and sodium arenesulfinates

An efficient synthetic route towards the synthesis of β-keto sulfones has been developed from secondary benzyl alcohols using N-bromosuccinimide (NBS). The present protocol utilizes NBS as oxidant as well as brominating agent, readily accessible benzyl alcohols and sodium arenesulfinates as the sulfonylating reagent under mild conditions. The control experiments revealed that the reaction proceeds via oxidation of alcohol to ketone, α-bromination of ketone and nucleophilic substitution by sodium arenesulfinate. Furthermore, the efficiency of the methodology was tested with a gram scale reaction and also shown the synthetic utility.

Novel Imidazole Derivatives Useful for the Treatment of Arthritis

The present invention provides compounds of the formula below: where A, X and R1-R6 are as described herein, a pharmaceutical salt thereof, and a pharmaceutical composition containing this compound; methods of treating pain associated with osteoarthritis using one of the compounds or a pharmaceutically acceptable salt thereof, and processes for preparing the compounds.

3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES

The present invention relates to 3,8-diaza-bicyclo[4.2.0]oct-8-yl amide derivatives of formula (I) Formula (I) wherein the relative configuration of the diazabicyclooctane moiety is cis; and wherein Ar1, and Ar 2 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.