701-71-3

Basic information

• Product Name: 1-fluoro-3-phenylpropan-2-ol
• CAS NO: 701-71-3
• Molecular Formula: C₉H₁₁FO
• Molecular Weight: 154.1814
• Mol File: 701-71-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 249.1°C at 760 mmHg
• Flash Point: 117.9°C
• Density: 1.085g/cm³
• Vapor Pressure: 0.0124mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: 1-fluoro-3-phenylpropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoro-3-phenylpropan-2-ol(701-71-3)
• EPA Substance Registry System: 1-fluoro-3-phenylpropan-2-ol(701-71-3)

Safety Data

• Hazardous Substances Data: 701-71-3(Hazardous Substances Data)

Usage

Classification

Fluoroalcohol

Contains

Fluorine atom and hydroxyl group

Usage

Organic synthesis and medicinal chemistry

Building block

Creation of other chemical compounds

Potential

Chiral auxiliary in asymmetric synthesis

Presence

Stereocenter on the carbon atom adjacent to the hydroxyl group

Applications

Development of pharmaceuticals and bioactive molecules

Unique structure

Contributes to its reactivity and potential uses

Versatility

Potential uses in various industries and research fields

Upstream product

• 503-09-3 epifluorohydrine 
• 591-51-5 phenyllithium 
• 4436-24-2 1,2-epoxy-3-phenylpropane 
• 1589-82-8 phenylmagnesium bromide 
• 1524-06-7 1-fluoro-3-phenylpropan-2-one 

Downstream Products

• 110270-43-4 (S)-α-(fluoromethyl)benzeneethanol 
• 336783-88-1 1-fluoromethyl-2-phenylethyl methanesulfonate 

Relevant articles and documents

Enantioselective radiosynthesis of positron emission tomography (PET) tracers containing [18F]fluorohydrins

Herein, we describe an operationally straightforward radiosynthesis of a chiral transition metal fluoride catalyst, [18F](salen)CoF, and its use for late-stage enantioselective aliphatic radiofluorination. We demonstrate the utility of the method by preparing single enantiomer experimental and clinically validated PET tracers that contain base-sensitive functional groups, epimerizable stereocenters, and nitrogen-rich motifs. Unlike the conventional radiosyntheses of these targets with [18F]KF, labeling with (salen)CoF is possible in the last step and under exceptionally mild conditions. These results constitute a rare example of a nucleophilic radiofluorination using a transition metal fluoride and highlight the potential of such reagents to enhance traditional methods for labeling aliphatic hydrocarbons.