70110-41-7Relevant academic research and scientific papers
Bis-Thiourea bearing aryl and amino acids side chains and their antibacterial activities
Wan Zullkiplee, Wan Sharifatun Handayani,Abd Halim, Ainaa Nadiah,Ngaini, Zainab,Mohd Ariff, Maya Asyikin,Hussain, Hasnain
, p. 832 - 838 (2014/07/08)
(Equation present) A series of symmetrical 1,3-bis thiourea 1a-e and 1,4-bis thiourea derivatives 2a-e have been successfully synthesized from the reactions of amines with 3-acetylbenzoyl isothiocyanate and 4-acetylbenzoyl isothiocyanate, respectively. All the synthesized compounds were characterized by FT-IR spectroscopy and 1H and 13C NMR spectroscopy. The compounds were screened for their antibacterial activity by turbidimetric method using gram-negative bacteria (E. coli ATCC 8739) using turbidimetric method. The newly synthesized bis-thiourea derivatives bearing aryl side chains showed good antibacterial activity against E. coli. The effect of the molecular structure of the synthesized compounds on the antibacterial activity is discussed. 2014 Copyright Taylor & Francis Group, LLC.
Efficient synthesis and biological evaluation of 1,3-benzenedicarbonyl dithioureas
Peng, Hao,Liang, Yongju,Chen, Le,Fu, Liwu,Wang, Haiqin,He, Hongwu
, p. 1102 - 1104 (2011/04/16)
The synthesis and biological activity of 1,3-benzenedicarbonyl dithioureas are described. Bioassay results indicated that these compounds exhibited cytotoxicity against various cancer cells. For example, compounds 4a showed the best inhibition activities against KB and CNE2 with IC50 10.72 and 9.91 μM, respectively.
Synthesis and anion recognition of molecular tweezers receptors based on acyl-thiourea
Wei, Tai-Bao,Wei, Wei,Cao, Cheng,Zhang, You-Ming
experimental part, p. 1218 - 1228 (2009/04/10)
Three title compounds were designed and synthesized in high yields as novel and simple anion receptors. They had a higher selectivity for F- over AcO-. The binding properties for anions of the receptors were examined by UV-Vis and 1H NMR spectroscopy. The spectrographic data indicate that a 1:1 stoichiometry complex is formed between the receptors and the anions through hydrogen bonding interactions in DMSO solution. In addition, these molecular tweezers receptors have more binding points of anions, larger association constant, and better recognition ability. They can be used as better recognition receptors for F- and CH3COO-. Copyright Taylor & Francis Group, LLC.
The anion recognition of simple-structure molecular tweezers receptors based on acyl-thiourea
Wei, Tai-Bao,Wei, Wei,Cao, Cheng,Zhang, You-Ming
, p. 1028 - 1032 (2008/09/18)
Three title compounds have been designed and synthesized in high yields as novel simple anion receptors. They have a high selectivity for F- and AcO-. The binding properties for anions of the receptors have been examined by UV-Vis and 1H NMR spectroscopy. The spectrographic data indicate that a 1:1 stoichiometry complex is formed between the receptors and the anions through hydrogen bonding interactions in DMSO solution.
