70112-91-3

Upstream product

• 99-63-8 benzene-1,3-dicarbonyl dichloride 
• 121-91-5 isophthalic acid 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 204503-46-8 1-{2-[3-(5-Acetyl-4-mercapto-6-methyl-pyrimidin-2-yl)-phenyl]-4-mercapto-6-methyl-pyrimidin-5-yl}-ethanone 
• 204503-55-9 {5-Acetyl-2-[3-(5-acetyl-4-ethoxycarbonylmethylsulfanyl-6-methyl-pyrimidin-2-yl)-phenyl]-6-methyl-pyrimidin-4-ylsulfanyl}-acetic acid ethyl ester 
• 204503-50-4 C₂₈H₁₈N₄O₆S₂ 
• 518061-32-0 N¹,N³-bis(p-tolylcarbamothioyl)isophthalamide 
• 70110-41-7 N,N'-bis(phenylcarbamothioyl)benzene-1,3-dicarboxamide 
• 1276662-34-0 C₂₂H₁₆F₂N₄O₂S₂ 
• 1276662-38-4 C₂₂H₁₈N₄O₄S₂ 
• 518061-36-4 C₂₂H₁₆Cl₂N₄O₂S₂ 
• 1036752-37-0 C₂₄H₂₂N₄O₄S₂ 
• 518061-37-5 N³,N^3'-bis(4-nitrophenyl)isophthalyl-bis(thiourea) 
• 518061-35-3 C₂₂H₁₆Cl₂N₄O₂S₂ 
• 1276662-32-8 C₂₂H₁₈N₄O₄S₂ 
• 518061-34-2 C₂₂H₁₆Cl₂N₄O₂S₂ 
• 1276662-36-2 N¹,N³-bis(o-tolylcarbamothioyl)isophthalamide 

Relevant academic research and scientific papers

Binuclear isophthaloylbis(N,N-diphenylthioureate) transition metal complexes: Synthesis, spectroscopic, thermal and structural characterization

The isophthaloylbis(N,N-diphenylthiourea) molecule (H2L ligand) reacts with CuI, CuII, MnIII, FeII, FeIII and CoII ions to form binuclear complexes with formula [M2(L-

Self-assembly of bis-[1]rotaxanes based on diverse thiourea-bridged mono-functionalized dipillar[5]arenes

The condensation reaction of mono-amido-functionalized pillar[5]arenes with tere- and iso-phthaloyl diisothiocyanates in acetone under ultrasonic irradiation afforded tere- and iso-phthaloylthiourea-bridged dipillar[5]arenes. The similar reaction of mono-

Bis-Thiourea bearing aryl and amino acids side chains and their antibacterial activities

(Equation present) A series of symmetrical 1,3-bis thiourea 1a-e and 1,4-bis thiourea derivatives 2a-e have been successfully synthesized from the reactions of amines with 3-acetylbenzoyl isothiocyanate and 4-acetylbenzoyl isothiocyanate, respectively. All the synthesized compounds were characterized by FT-IR spectroscopy and 1H and 13C NMR spectroscopy. The compounds were screened for their antibacterial activity by turbidimetric method using gram-negative bacteria (E. coli ATCC 8739) using turbidimetric method. The newly synthesized bis-thiourea derivatives bearing aryl side chains showed good antibacterial activity against E. coli. The effect of the molecular structure of the synthesized compounds on the antibacterial activity is discussed. 2014 Copyright Taylor & Francis Group, LLC.

Study of antioxidant, cytotoxic, and enzyme inhibition activities of some symmetrical N3,N3'-Bis(disubstituted)isophthalyl-bis(thioureas) and N3,N3,N3',N3'-Tetrakis(disubstituted)isophthalyl-bis(thioureas) and their Cu(II) and Ni(II) complexes

The present study includes the evaluation of antioxidant, cytotoxic, antiureas and some other enzymes like a-chymotrypsin, acetylcholinesterse, butyrylcholinesterase inhibition activity of some synthesized N3,N3'-bis(disubstituted)isophthalyl-bis(thioureas) and N3,N3,N3',N3'- tetrakis(disubstituted)isophthalyl-bis(thiourea) compounds with general formula [C6H4{CONHCSNR1R2}2], where R1 = H (L1-L5), C6H6(L6), and R2 = 4-C6H4COOH(L1), 3- NO2C6H4(L2), 2-NO2C6H4(L3), 4-NO2C6H4(L4), C5H4N(L5) and C6H11(L6) and their Cu(II) and Ni(II) complexes. The antioxidant inhibition was measured against standard butylated hydroxyl toluene for all the synthesized compounds. Thiourea used as standard against antiureas inhibition. The enzyme inhibition IC50 values were used to describe the results. The results of these studies also show that the metal (II) complexes have more potential activity against different enzymatic inhibitions as compared to uncomplexed ligands. The results reveal that synthesized thioureas and their metal (II) complexes can be used as potential inhibitors against some disease causing enzymes like ureas etc.

Synthesis, characterization and antibacterial activity of some novel symmetrical N3, N3'-Bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes

A series of some novel N3,N3'-bis(disubstituted) isophthalyl-bis(thioureas) compounds with general formula [C6H 4{CONHCSNHR}2], where R = 4-C6H 4COOH(L1), 3-NO2C6H 4(L2), 2- NO2C6H4(L 3), 4-CH3C6H4(L4), 2-CH3C6H4(L5), 3-CH 3C6H4(L6) and their Cu(II) and Ni(II) complexes have been synthesized. (L1-L6) have been prepared in good to excellent yields by reaction of isophthaloyl isothiocyanate with primary amines using dry acetone as solvent. The stoichiometric reaction between the metal (II) ion and synthesized ligands in molar ratio of M : L (1 : 1) resulted in the formation of the metal complexes of type [ML]2 (where M = Cu(II) and Ni(II). These compounds (L1-L6) and their metal (II) complexes have been characterized by elemental analyses, Infrared spectroscopy, 1H-NMR spectroscopy, magnetic moments, and electronic spectral measurements. These compounds (L1-L6) and their metal (II) complexes were also screened for their antibacterial activity against bacterial species, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Shigella sonnei, Salmonella typhi and Pseudomonas aeroginosa. Some compounds showed potential activity against a number of bacterial strains. The results of these studies also show the metal (II) complexes to be having stronger antibacterial activityl against one or more species as compared to the uncomplexed ligands. It was concluded that these compounds may be the potential source of active antibacterial agents.

Synthesis, characterization, antibacterial and urease inhibition studies of some novel symmetrical N3,N3'-bis-(disubstituted)isophthalyl-bis-(thioureas)

A series of some novel N3,N3'-bis-(disubstituted)isophthalyl-bis- (thioureas), with general formula [ C>inf/infinf/ infinf/infinf/infinf/ infinf/ infinf/infinf/ infinf/infinf/ infinf/infinf/ infinf/infinf/infinf/infinf/ infinf/inf(4j) have been synthesized in good to excellent yields by reaction of isophthaloyl isothiocyanate with primary and secondary amines using dry acetone as solvent. These compounds 3a-j have been characterized by elemental analyses, infrared and 1H NMR spectroscopy. These compounds were screened for their antibacterial activity against bacterial species, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, S. sonii, Salmonella typhi and Pseudomonas aeroginosa. Some compounds showed potent activity against some bacterial strains and others exhibited strong antibacterial activity. The synthesized compounds 4a-j were also evaluated for urease inhibition and found to exhibit varying degree of urease inhibition activity. Compounds 4a-d were found to be the most active, exhibiting IC50 = 26.3 ± 0.5 to 31.1 ± 0.3 μM. It was concluded that these compounds may be a potential source of active antibacterial agents and some of these compounds also exhibit promising urease inhibitory activity.

Synthesis, characterization and antibacterial activity of some novel symmetrical N3,N3'-Bis(disubstituted)isophthalyl- bis(thioureas) and N3,N3,N3',N 3'-Tetrakis(disubstituted)isophthalyl-bis(thiourea) and their Cu(II) and Ni(II) Complexes

A series of some novel N3,N3'-bis(disubstituted) isophthalyl-bis(thioureas) and N3,N3,N3',N 3'-Tetrakis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [C6H4{CONHCSNR1R}2], where R1 = H (1-4), C6H11(5), C 6H5(6) and R2 = 4-NO2C 6H4(1), C6H11(2), 2,4(CH 3)2C6H3(3), C5H4N(4), C6H11(5), C6H5(6), and their Cu(II) and Ni(II) complexes have been synthesized. (L1-L6) have been synthesized in good to excellent yields by reaction of isophthaloyl isothiocyanate with primary and secondary amines using dry acetone as solvent. The stoichiometric reaction between the metal (II) ion and synthesized ligands in molar ratio of M : L (1 : 1) resulted in the formation of the metal complexes of type [ML]2 (where M = Cu(II) and Ni(II). These compounds (L 1-L6) and their metal (II) complexes have been characterized by elemental analyses, Infrared spectroscopy, 1H-NMR spectroscopy, magnetic moments, and electronic spectral measurements. These compounds (L1-L6) and their metal (II) complexes were also screened for their antibacterial activity against bacterial species, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, S. sonii, Salmonella typhi and Pseudomonas aeroginosa. Some compounds showed potential activity against some bacterial strains than others. The results of these studies also show the metal (II) complexes to be more antibacterial against one or more species as compared to the uncomplexed ligands. It was concluded that these compounds may be a potential source of active antibacterial agents.

Synthesis and characterization of novel thermally stable aromatic and semiaromatic polyamides derived from thiourea-based flexible diacid dichlorides

New diacid dichlorides bearing phenyl thiourea groups were prepared by a facile synthetic approach and characterized using spectroscopic and elemental analyses. A series of novel aromatic and semiaromatic polyamides were prepared via a condensation route

Efficient synthesis and biological evaluation of 1,3-benzenedicarbonyl dithioureas

The synthesis and biological activity of 1,3-benzenedicarbonyl dithioureas are described. Bioassay results indicated that these compounds exhibited cytotoxicity against various cancer cells. For example, compounds 4a showed the best inhibition activities against KB and CNE2 with IC50 10.72 and 9.91 μM, respectively.

The anion recognition of simple-structure molecular tweezers receptors based on acyl-thiourea

Three title compounds have been designed and synthesized in high yields as novel simple anion receptors. They have a high selectivity for F- and AcO-. The binding properties for anions of the receptors have been examined by UV-Vis and 1H NMR spectroscopy. The spectrographic data indicate that a 1:1 stoichiometry complex is formed between the receptors and the anions through hydrogen bonding interactions in DMSO solution.