701197-79-7

Upstream product

• 226212-77-7 methyl (2S) 2-N-tosyl-2-N-tert-butylcarboxymethyl-4-N-benzyloxycarbonyl-(2,4)-diaminobutyrate 
• 98-59-9 p-toluenesulfonyl chloride 
• 226212-75-5 methyl (2S) 2-N-tert-butyloxycarbonyl-4-N-benzyloxycarbonyl-(2,4)-diaminobutyrate 
• 110662-68-5 methyl (2S) 2-N-tosyl-4-N-benzyloxycarbonyl-(2,4)-diaminobutyrate 
• 55528-35-3 methyl (2S) 4-N-benzyloxycarbonyl-(2,4)-diaminobutyrate 

Relevant academic research and scientific papers

Synthesis of perhydrodiazepinones as new putative peptidomimetics

New functionalized 7-membered azaheterocycles (perhydrodiazepinones) have been designed as new scaffolds supposed to mimick peptide γ-turns constrained by an ethylene bridge. They were synthesized by either lactam cyclisation on an aminoacid compound outcoming from a glutamic acid derivative starting material or through an intramolecular Mitsunobu reaction on diaminoalcohol linear precursors. Furthermore, as a new strategy useful for combinatorial chemistry, the second synthesis has been investigated on a soluble polymer support (PEG).