7012-79-5Relevant academic research and scientific papers
Copper-catalyzed direct amination of ortho-functionalized haloarenes with sodium azide as the amino source
Zhao, Haibo,Fu, Hua,Qiao, Renzhong
, p. 3311 - 3316 (2010)
A simple copper-catalyzed direct amination of ortho-functionalized haloarenes (2-halobenzoic acid, 2-halobenzamide, and N-(2-bromophenyl)acetamide derivatives) has been developed with use of NaN3 as the amino source in ethanol, and the corresponding ortho-functionalized aromatic amines were synthesized in good to excellent yields. The protocol undergoes one-pot Ullmann-type coupling of ortho-functionalized haloarenes with NaN3 to lead to ortho-functionalized azidoarenes, followed by reduction with ethanol.
