70124-98-0

Usage

Uses

Used in Cancer Research:
2-(P-HYDROXYPHENYL)ISOVALERIC ACID is used as a potential biomarker for identifying certain types of cancer, aiding in early detection and diagnosis.
Used in Neurodegenerative Disease Treatment:
2-(P-HYDROXYPHENYL)ISOVALERIC ACID is being studied for its potential role in treating neurodegenerative diseases, offering hope for new therapeutic approaches.
Used in Anti-Inflammatory Applications:
2-(P-HYDROXYPHENYL)ISOVALERIC ACID is used as an anti-inflammatory agent, leveraging its properties to reduce inflammation and alleviate symptoms associated with various conditions.
Used in Antioxidant Therapy:
2-(P-HYDROXYPHENYL)ISOVALERIC ACID is used as an antioxidant, protecting cells from damage caused by reactive oxygen species and potentially slowing down aging and disease progression.
Used in Pharmaceutical Development:
2-(P-HYDROXYPHENYL)ISOVALERIC ACID is used as a target for the development of new drugs, given its multifaceted potential in treating various diseases and conditions.

InChI:InChI=1/C11H14O3/c1-7(2)10(11(13)14)8-3-5-9(12)6-4-8/h3-7,10,12H,1-2H3,(H,13,14)

Upstream product

• 51632-18-9 2-(4-methoxyphenyl)-3-methylbutyronitrile 
• 67033-46-9 2-(4-hydroxyphenyl)-3-methylbutyronitrile 
• 2012-81-9 3-Methyl-2-(4'-chlorophenyl)-butyronitrile 
• 12775-96-1 copper 

Downstream Products

• 110-86-1 pyridine 
• 70124-99-1 ⁽²⁾-2-(4-difluoromethoxyphenyl)-3-methylbutyric acid 
• 72222-38-9 α-isopropyl-3-nitro-4-hydroxyphenylacetic acid 
• 72222-37-8 α-isopropyl-3,5-dichloro-4-hydroxyphenylacetic acid 
• 72222-36-7 α-isopropyl-3-chloro-4-hydroxyphenylacetic acid 
• 72222-35-6 α-Isopropyl-3-bromo-4-hydroxyphenylacetic acid 
• 88149-98-8 methyl-2-(4-hydroxyphenyl)-3-methylbutanoate 

Relevant academic research and scientific papers

Process for the preparation of 2-(4-hydroxyphenyl)-3-methylbutyric acid

An integrated process for the preparation of 2-(4-hydroxyphenyl)-3-methylbutyric acid from the corresponding 2-(4-chlorophenyl)-3-methylbutyronitrile through hydrolysis of the nitrile by strong base to the corresponding carboxylic acid followed by formation of the corresponding phenol by nucleophilic displacement of the chlorine with a strong base in the presence of copper salts, and if so desired metallic copper, is described.

Method of preparing 4-(α-alkyl-α-cyano-methyl)2,6-di-substituted phenols

4-(α-alkyl-α-cyano-methyl)2,6-di-substituted phenols having the formula STR1 wherein R is methyl, ethyl, n-propyl or isopropyl are prepared by reacting a di-substituted phenol, such as 2,6-di-tertiary-butyl phenol, with a Friedel-Crafts addition agent in the presence of a Friedel-Crafts catalyst such as aluminum chloride to form the corresponding 4-(α-alkyl-α-oxo-methyl)2,6-di-substituted phenol. The 4-(α-alkyl -α-oxo-methyl)2,6-di-substituted phenol thus formed readily can be reduced to form the corresponding 4-(α-alkyl-α-hydroxy-methyl)2,6-di-substituted phenol which thereafter can be reacted with an alkali metal or an alkaline earth metal cyanide to form the desired 4-(α-alkyl-α-cyano-methyl)2,6-di-substituted phenol. This can be converted by hydrolysis into the corresponding α-alkyl-4-hydroxyphenylacetic acid. These acids are well-known insecticidal and acaricidal intermediates.

Process for preparing phenylalkanoic acids

Hydroxyphenylacetic acids are formed from the corresponding benzaldehydes or alkyl phenyl ketones by reduction, cyanation and hydrolysis without isolation or purification of intermediate products.

Method for the alkylation of phenylacetonitriles

A method for the alkylation of certain substituted phenylacetonitriles with alkylhalides in the presence of solid particulated alkali metal hydroxides under essentially anhydrous conditions. Trialkylamine catalysts may optionally be utilized. Compounds obtained by this method, some of which are valuable intermediates in the preparation of pyrethroid pesticides, are described.