2012-81-9

Basic information

• Product Name: 2-(4-CHLOROPHENYL)-3-METHYLBUTYRONITRILE
• Synonyms: 2-(P-CHLOROPHENYL)-3-METHYLBUTYRONITRILE;2-(4-CHLOROPHENYL)-3-METHYLBUTYRONITRILE;ALPHA-ISOPROPYL-4-CHLOROPHENYLACETONITRILE;CPIN;2-(4-Chlorophenyl)-3-methylbutanenitrile;4-Chloro-(1-methylethyl)benzene-acetonitrile;4-chloro-a-(1-methylethyl)benzeneacetonitrile;4-chloro-alpha-(1-methylethyl)-benzeneacetonitril
• CAS NO: 2012-81-9
• Molecular Formula: C₁₁H₁₂ClN
• Molecular Weight: 193.67
• EINECS: 217-935-7
• Mol File: 2012-81-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 317.7°C (rough estimate)
• Flash Point: 107.2 °C
• Appearance: /
• Density: 1.1225 (rough estimate)
• Vapor Pressure: 0.00526mmHg at 25°C
• Refractive Index: 1.6100 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-CHLOROPHENYL)-3-METHYLBUTYRONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENYL)-3-METHYLBUTYRONITRILE(2012-81-9)
• EPA Substance Registry System: 2-(4-CHLOROPHENYL)-3-METHYLBUTYRONITRILE(2012-81-9)

Safety Data

• Hazardous Substances Data: 2012-81-9(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenyl)-3-methylbutyronitrile is a chemical compound with the molecular formula C12H14ClN. It is known for its use as an intermediate in the synthesis of pharmaceutical compounds and other organic chemicals. 2-(4-CHLOROPHENYL)-3-METHYLBUTYRONITRILE is classified as a nitrile, containing a carbon-nitrogen triple bond, and is characterized by the presence of a 4-chlorophenyl group and a 3-methylbutyronitrile group. It is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and compounds. Additionally, it is utilized in research and development for the synthesis of new chemical entities and as a reagent in chemical reactions. Due to its versatile chemical nature, 2-(4-Chlorophenyl)-3-methylbutyronitrile plays a crucial role in the production and development of various pharmaceutical and organic chemical products.

InChI:InChI=1/C11H12ClN/c1-8(2)11-7-10(12)4-3-9(11)5-6-13/h3-4,7-8H,5H2,1-2H3

Upstream product

• 75-26-3 isopropyl bromide 
• 140-53-4 p-chlorobenzyl cyanide 
• 4395-87-3 (4-isopropylphenyl)acetonitrile 
• 75-29-6 isopropyl chloride 
• 622-95-7 4-chlorobenzyl bromide 
• 106-43-4 para-chlorotoluene 
• 14774-78-8 4-chlorophenyl lithium 

Downstream Products

• 51630-58-1 FENVALERATE 
• 51631-50-6 2-(4-chlorophenyl)-3-methyl-(2SR)-butanoyl chloride 
• 70124-98-0 2-(4'-hydroxyphenyl)-3-methylbutanoic acid 
• 131691-15-1 2-(4-Chloro-phenyl)-3-methyl-butyric acid 3-methyl-4-oxo-2-phenyl-4H-chromen-7-yl ester 
• 131691-14-0 flavone-7-yl α-isopropyl-4-chlorophenylacetate 
• 131691-10-6 2-(4-Chloro-phenyl)-3-methyl-butyric acid 2-(2-methyl-5-nitro-imidazol-1-yl)-ethyl ester 
• 131691-17-3 6-chlorocoumarin-4-yl α-isopropyl-4-chlorophenylacetate 
• 131691-16-2 2-(4-Chloro-phenyl)-3-methyl-butyric acid 2-oxo-2H-chromen-4-yl ester 
• 120352-45-6 2-(4-Chloro-phenyl)-2-isopropyl-5-{[3-(3-methoxy-phenoxy)-propyl]-methyl-amino}-pentanenitrile 
• 120351-84-0 2-(1-methylethyl)-5-oxo-2-(4-chlorophenyl)pentane nitrile 
• 120352-19-4 2-(4-Chloro-phenyl)-2-isopropyl-5-[3-(3-methoxy-phenoxy)-propylamino]-pentanenitrile 
• 55332-38-2 S-isopropyl-4-chlorophenylacetic acid 
• 69741-69-1 2-(4-chlorophenyl)-3-methylbutyramide 
• 2012-74-0 2-(4-chlorophenyl)-3-methylbutyric acid 

Relevant articles and documents

Novelties of solid-liquid phase transfer catalysed synthesis of α-isopropyl-p-chlorophenyl acetonitrile from p-chlorophenyl acetonitrile

C-Alkylation is an important class of synthetic reaction employed in the fine chemical industry. Although a number of C-alkylation reactions are reported under liquid-liquid (L-L) phase transfer catalysis (PTC) leading to intensification of reaction rates, there is a dearth of information on similar reactions under the solid-liquid (S-L) PTC including kinetics and mechanism. S-L PTC offers higher rates of reaction and better selectivities to the desired product vis-a-vis L-L PTC. This contribution reports the novelties of S-L PTC for C-alkylation of p-chlorophenyl acetonitrile to α-isopropyl-p-chlorophenyl acetonitrile which is an important intermediate in the synthesis of a pyrethroid insecticide named fenvalerate. p-Chlorophenyl acetonitrile can be mono- or dialkylated, depending on the reaction conditions, and it is a versatile synthetic intermediate in the sense that the nitrile function can be hydrolysed, reduced, or added to by organometallics after an alkylation has been carried out. It is found that the S-L PTC process is more intensified and selective. The mechanistic details of C-alkylation under basic conditions and the unexpected side reaction of oxidative decyanation are studied. The production of water as a byproduct in the reaction to form the omega (ω) phase and the mechanism in reference to the S-L-ω-phase system is described. A numerical model is composed to calculate the values of various pseudo rate constants and validate the simulated profiles against experimental data. The finer aspects of selectivity in C-alkylation reaction are analysed.

Synthesis, insecticidal and antifeedant activities of new type of pyrethroid esters

-

Optical Resolution of 2-(4-Substituted phenyl)-3-methylbutanoic Acids with Diethylamine by Preferential Crystallization

(+/-)-2-(4-Substituted phenyl)-3-methylbutanoic acids (2a-c) were optically resolved by preferential crystallization in the form of their diethylamine salts (3a-c).The molar ratio of the acid to the amine in these salts was found to be 2:1 by chemical analyses, and was confirmed by analyzing the crystal structure of one of these salts (3b) with X-ray single crystallography.