701243-16-5Relevant academic research and scientific papers
Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors
Pecchi, Sabina,Renhowe, Paul A.,Taylor, Clarke,Kaufman, Susan,Merritt, Hanne,Wiesmann, Marion,Shoemaker, Kevin R.,Knapp, Mark S.,Ornelas, Elizabeth,Hendrickson, Thomas F.,Fantl, Wendy,Voliva, Charles F.
supporting information; scheme or table, p. 6895 - 6898 (2011/02/26)
PI3 Kinases are a family of lipid kinases mediating numerous cell processes such as proliferation, migration, and differentiation. The PI3 kinase pathway is often de-regulated in cancer through PI3Kα overexpression, gene amplification, mutations, and PTEN
2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER
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Page 62; 70, (2008/06/13)
Compounds having formula I are provided where the variables have the values described herein. (I). Pharmaceutical formulations include the compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and combinations with other agents. A method of treating a patient comprises administering a pharmaceutical formulation according to the invention to a patient in need thereof.
