70127-50-3Relevant academic research and scientific papers
Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action
Lyubina, Anna P.,Mironov, Vladimir F.,Pashirova, Tatiana N.,Sapunova, Anastasiia S.,Shaihutdinova, Zukhra M.,Tatarinov, Dmitry A.,Terekhova, Natalia V.,Voloshina, Alexandra D.,Zakharova, Lucia Ya.
, (2020/05/19)
Here we report the synthesis and biological evaluation of a series of new 2-hydroxybenzylphosphonium salts (QPS) with antimicrobial and antitumor dual action. The most active compounds exhibit antimicrobial activity at a micromolar level against Gram-positive bacteria Sa (ATCC 209p and clinical isolates), Bc (1–2 μM) and fungi Tm and Ca, and induced no notable hemolysis at MIC. The change in nature of substituents of the same length led to a drastic change of biological activity. Self-assembly behavior of the octadecyl and oleyl derivatives was studied. QPS demonstrated self-assembly within the micromolar range with the formation of nanosized aggregates capable of the solubilizing hydrophobic probe. The synthesized phosphonium salts were tested for cytotoxicity. The most potent salt was active against on M?Hela cell line with IC50 on the level of doxorubicin and good selectivity. According to the cytofluorimetry analysis, the salts induced mitochondria-dependent apoptosis.
2-Ethoxy-2,3-dihydro[d][1,2]oxaphosphole 2-oxide in the synthesis of dialkyl(diaryl)(2-hydroxybenzyl)phosphine oxides
Tatarinov,Kuznetsov,Kostin,Mironov
, p. 530 - 533 (2016/06/01)
A facile method of synthesis of functionally substituted P(IV) derivatives―dialkyl(diaryl)(2-hydroxybenzyl) phosphine oxides―by the reaction of 2-ethoxy-2,3-dihydro[d][1,2]oxaphosphole 2-oxide with organomagnesium compounds, which allows wide variation of
Ph2PI as a reduction/phosphination reagent: Providing easy access to phosphine oxides
Wang, Feijun,Qu, Mingliang,Chen, Feng,Xu, Qin,Shi, Min
supporting information; experimental part, p. 8580 - 8582 (2012/09/22)
The reaction of aldehydes with Ph2PI provides a facile way to the synthesis of pentavalent phosphine compounds with moderate to good yields.
Hydrophosphanation of phenolic aldehydes as facile synthetic approach to catechol-functionalized phosphane oxides and phosphanes
Chikkali, Samir,Gudat, Dietrich
, p. 3005 - 3009 (2007/10/03)
Reactions of diphenylphosphane with mono- and dihydroxy-benzaldehydes yield as initial products α-phosphanyl-carbinols that exist according to NMR studies in dynamic equilibrium with the starting materials in solution but are stable in the solid state. Th
Trimethylsilyl halide-promoted Michaelis-Arbuzov rearrangement
Renard, Pierre-Yves,Vayron, Philippe,Mioskowski, Charles
, p. 1661 - 1664 (2007/10/03)
(Matrix presented) We describe a new, straightforward, and easy-to-handle method for achieving an unprecedented trimethylsilyl halide-catalyzed Michaelis-Arbuzov-like rearrangement. This rearrangement occurs at temperatures from room temperature to 80°C and does not require addition of any alkyl halide. The scope and limitations of this new reaction are explored, as well as its mechanism.
(2-Hydroxyphenylmethylene)bis(phosphine oxides): a Facile Rearrangement into 2-(Phosphinylmethyl)phenyl Phosphinates
Bovin, Alexander N.,Yarkevich, Alla N.,Kharitonov, Alexander V.,Tsvetkov, Eugene N.
, p. 973 - 974 (2007/10/02)
(2-Hydroxyphenylmethylene)bis(phosphine oxides) 3 prepared from 2-(diphenylphosphinylmethyl)phenyl phosphinates 2 by oxygen-to-carbon 1,4-phosphinyl migration easily rearrange back into a mixture of 2-(phosphinylmethyl)phenyl phosphinates 2 and 4 under ba
PHOSPHORUS-CONTAINING PODANDS. 4. EFFECT OF POLYETHER CHAIN LENGTH OF OLIGOETHYLENE GLYCOL BIS(ORTHO-DIPHENYLPHOSPHINYLMETHYL)PHENYL ETHERS ON THEIR COMPLEX-FORMING AND SELECTIVE PROPERTIES WITH RESPECT TO ALKALI METAL CATIONS
Evreinov,V. I.,Baulin, V. E.,Vostroknutova, Z. N.,Bondarenko, N. A.,Syundyukova, V. Kh.,Tsvetkov, E. N.
, p. 1828 - 1834 (2007/10/02)
Alkylation of o-(diphenylphosphinylmethyl)phenol by oligoethylene glycol ditosylates leads to a series of acyclic polyether complexing agents (podands) with phosphinylmethylphenyl terminal groups.A conductometric method in tetrahydrofuran-chloroform (4:1 by volume) has been used to determine the stability constants of the pobands with alkali metal 2,4-dinitrophenoxides.Several of the prepared ligands exhibited a high Li/Na, Na/K, and Li/K selectivity.For lithium and sodium cations, the curve of complex-forming ability against the overall number of donor centers in the structure of the podand has a maximum for the case of tetraethylene glycol bis(o-diphenylphosphinylmethyl)phenyl ether.For lithium cations, this compound surpasses the crown ethers in terms of its effectiveness and is the most powerful of the phosphoryl-containing complexing agents.For potassium, rubidium, and cesium cations, the complex-forming ability increases with increase in the number of oxygen donor centers in the polyether chain of the ligand.
Phosphinylmethyl polypenols and polyglycidyl ethers thereof
-
, (2008/06/13)
Novel phosphorus-containing polyglycidyl ethers capable of forming a cured epoxy resin having a high flame retardancy and excellent in heat resistance characteristics such as heat deterioration resistance, glass transition temperature, thermal deformation
