70128-19-7

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-5-HYDROXYBENZALDEHYDE is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into various drug molecules, contributing to their therapeutic properties.
Used in Organic Compounds Synthesis:
2-AMINO-5-HYDROXYBENZALDEHYDE is used as a building block in the synthesis of other organic compounds, leveraging its reactive functional groups to form a wide range of chemical products.
Used in Antimicrobial Applications:
2-AMINO-5-HYDROXYBENZALDEHYDE is used as an antimicrobial agent for its potential to inhibit the growth of microorganisms, which can be beneficial in the development of new antimicrobial drugs and materials.
Used in Antioxidant Formulations:
2-AMINO-5-HYDROXYBENZALDEHYDE is used as an antioxidant in formulations to protect against oxidative stress and damage, which can be useful in the development of health supplements and materials with enhanced durability.

Upstream product

• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 

Downstream Products

• 75434-18-3 6-hydroxyquinoline-2-carboxylic acid 
• 161914-18-7 C₁₂H₁₅NO₄ 
• 161914-17-6 S-0139 
• 161914-16-5 (E)-5-hydroxy-2-(3-methoxycarbonylacryloylamino)benzaldehyde 
• 193969-63-0 C₁₂H₁₁NO₅ 

Relevant academic research and scientific papers

Repurposing an Aldolase for the Chemoenzymatic Synthesis of Substituted Quinolines

Quinoline derivatives are important natural products and pharmaceuticals, but their synthesis can be challenging due to poor yields, harsh reaction conditions, and instability of starting materials. Here we report the chemoenzymatic synthesis of quinaldic acids under mild conditions using an aldolase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (NahE, or HBPA). A series of 2-aminobenzaldehydes derived from reduction of the corresponding nitro analogue were reacted with pyruvate in the presence of NahE to give substituted quinolines in up to 93% isolated yield. This reaction differs from the aldol condensation catalyzed by NahE in vivo, instead resembling the heterocycle formation catalyzed by its homologue, dihydrodipicolinate synthase.

NOVEL CRYSTAL OF TRITERPENE DERIVATIVE

Disclosed herein are a novel crystal of a novel triterpene derivative, a method for producing the crystals, and a pharmaceutical preparation obtained by using the crystals. The novel crystal is a crystal of a compound (I) of the formula (I):

PROCESS FOR PRODUCING TRITERPENE DERIVATIVE

A process for a preparation of Compound (V), a pharmaceutically acceptable salt or a solvate thereof, said process comprising the steps represented by the following formula: wherein R1 and R2 are each independently C1 - C8 alkyl

Practical large-scale synthesis of endothelin receptor antagonist S-0139

Semisynthetic endothelin receptor antagonist S-0139 was synthesized in 14 steps from oleanolic acid 2 in a 20% overall yield on a multi-kilogram scale. Our previous synthesis of the oleanane skeleton was modified and improved to give phosphonate 9 as a ke