75434-18-3

Usage

Uses

Used in Pharmaceutical Synthesis:
6-Hydroxy-2-quinolinecarboxylic acid is used as a precursor in the synthesis of pharmaceuticals for its ability to be chemically modified to create a variety of medicinal compounds. Its presence in the molecular structure of certain drugs makes it a valuable component in the development of new therapeutic agents.
Used in Agrochemical Production:
In the agrochemical industry, 6-Hydroxy-2-quinolinecarboxylic acid is used as a starting material for the production of various agrochemicals. Its role in creating effective compounds for pest and disease control in agriculture highlights its utility in ensuring crop protection and yield enhancement.
Used in Antimicrobial Treatments:
6-Hydroxy-2-quinolinecarboxylic acid is used as an antimicrobial agent for its properties in treating bacterial infections. 6-Hydroxy-2-quinolinecarboxylic acid's ability to interfere with microbial processes makes it a potential candidate for developing new antibiotics or antimicrobial products.
Used as an Antioxidant:
6-Hydroxy-2-quinolinecarboxylic acid is utilized as an antioxidant due to its capacity to neutralize free radicals. This function is vital in various applications, such as in the food industry to extend shelf life and in the cosmetic industry to protect against oxidative stress.
Used in Materials Science:
In the field of materials science, 6-Hydroxy-2-quinolinecarboxylic acid is employed in the development of new materials. Its chemical properties allow it to be integrated into the composition of advanced materials with specific characteristics, such as conductivity or catalytic activity, broadening its scope in technological applications.
Overall, 6-Hydroxy-2-quinolinecarboxylic acid's diverse applications in medicine, agriculture, and materials science underscore its importance as a versatile chemical compound with significant potential for future research and development.

Upstream product

• 75433-99-7 6-Methoxy-quinoline-2-carboxylic acid 
• 580-16-5 6-hydroxyquinoline 
• 93499-73-1 6-hydroxyquinoline 1-oxide 
• 52313-34-5 6-hydroxyquinoline-2-carbonitrile 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 
• 70128-19-7 2-amino-5-hydroxybenzaldehyde 
• 57-60-3 piruvate 

Downstream Products

• 1427753-53-4 6-(benzyloxy)quinoline-2-carbaldehyde 
• 1427753-52-3 benzyl 6-(benzyloxy)quinoline-2-carboxylate 
• 1219397-09-7 6-hydroxy-1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester 
• 429687-75-2 6-hydroxyquinoline-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Repurposing an Aldolase for the Chemoenzymatic Synthesis of Substituted Quinolines

Quinoline derivatives are important natural products and pharmaceuticals, but their synthesis can be challenging due to poor yields, harsh reaction conditions, and instability of starting materials. Here we report the chemoenzymatic synthesis of quinaldic acids under mild conditions using an aldolase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (NahE, or HBPA). A series of 2-aminobenzaldehydes derived from reduction of the corresponding nitro analogue were reacted with pyruvate in the presence of NahE to give substituted quinolines in up to 93% isolated yield. This reaction differs from the aldol condensation catalyzed by NahE in vivo, instead resembling the heterocycle formation catalyzed by its homologue, dihydrodipicolinate synthase.

Thio hydantoin ternary and circular androgen receptor antagonists and use thereof (by machine translation)

The invention relates to the field of pharmaceutical chemistry, and in particular relates to a category of thio hydantoin and indoline skeleton has the role of the anti-prostate cancer compound (I) and (II), a method for preparing these compounds, these c

6-HETEROARYLOXY- OR 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND METHOD OF USE

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Selective naphthalene H3 receptor inverse agonists with reduced potential to induce phospholipidosis and their quinoline analogs

We reported earlier the refinement of our initial five-point pharmacophore model for the Histamine 3 receptor (H3R), with a new acceptor feature important for binding and selectivity against the other histamine receptor subtypes 1, 2 and 4. This approach was validated with a new series of H3R inverse agonists: the naphthalene series. In this Letter, we describe our efforts to overcome the phospholipidosis flag identified with our initial lead compound (1a). During the optimization process, we monitored the potency of our molecules toward the H3 receptor, their selectivity against H1R, H2R and H4R, as well as some key molecular properties that may influence phospholipidosis. Encouraged by the promising profile of the naphthalene series, we used our deeper understanding of the H3R pharmacophore model to lead us towards the quinoline series. This series is perceived to have intrinsic advantages with respect to its amphiphilic vector.

QUINOLINE DERIVATIVES AS H3R INVERSE AGONISTS

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

Bicyclo 4.4.0 antiviral derivatives

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity

1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids

A series of 1-[acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids and salts thereof are useful as Angiotensin I converting enzyme inhibitors.