70132-76-2

Upstream product

• 5162-03-8 (2-chlorophenyl)(phenyl)methanone 
• 344244-72-0 C₂₃H₂₁NO₂S 
• 174532-69-5 2-mercaptobenzhydrylidenamine 
• 1620-95-7 [2-(methylthio)phenyl](phenyl)methanone 
• 1442-03-1 2-methylsulfanyl-benzoyl chloride 
• 62076-10-2 (tert-butylsulfinyl)benzene 
• 108-86-1 bromobenzene 
• 100-68-5 methyl-phenyl-thioether 
• 67-56-1 methanol 
• 344262-41-5 C₂₄H₂₃NO₂S 
• 1013-88-3 Benzophenone imine 
• 13047-06-8 o-bromobenzophenone 
• 100-47-0 benzonitrile 
• 342-24-5 o-fluorobenzophenone 

Downstream Products

• 80816-78-0 (6R,7R)-6,7-Dimethyl-9-phenyl-6,7-dihydro-5-thia-8-aza-benzocycloheptene 
• 78134-70-0 3-Ethoxy-5-phenyl-2,3-dihydro-1,4-benzothiazepine 
• 38210-55-8 2-(Diethylamino)-3-phenylbenzothiophene 
• 84538-83-0 4-(Diethylamino)-3-methyl-1-phenylisoquinoline 
• 84538-80-7 1-(Diethylamino)-7-methyl-5-phenyl-3,4-benzo-2,6-thiazabicyclo<3.2.0>hepta-3,6-diene 
• 57642-62-3 2-methyl-3-phenylbenzothiophen 
• 84538-78-3 3-Ethoxy-4-methyl-1-phenylisoquinoline 
• 84538-74-9 7-Ethoxy-1-methyl-5-phenyl-3,4-benzo-2,6-thiazabicyclo<3.2.0>hepta-3,6-diene 
• 14315-12-9 3-phenyl-1-benzothiophene 
• 84538-77-2 3-ethoxy-1-phenyl-isoquinoline 
• 84538-88-5 5-Phenyl-3,4-benzo-2,6-thiazabicyclo<3.2.0>hept-3-en-7-one 
• 84538-73-8 7-Ethoxy-5-phenyl-3,4-benzo-2,6-thiazabicyclo<3.2.0>hepta-3,6-diene 
• 84538-85-2 Ethyl 2,3-dihydro-3-amino-3-phenylbenzothiophenyl-2-carboxylate 
• 80824-65-3 [2-(2-Amino-1,1,2-trimethyl-propylsulfanyl)-phenyl]-phenyl-methanone 

Relevant academic research and scientific papers

Synthesis of Isothiazoles and Isoselenazoles through Rhodium-Catalyzed Oxidative Annulation with Elemental Sulfur and Selenium

A rhodium-catalyzed oxidative annulation of benzimidates with elemental sulfur for the direct construction of isothiazole rings is reported. The proposed reaction mechanism involving Rh(I)/Rh(III) redox is supported by a stoichiometric reaction of metallacycle species as well as DFT calculations. This method is also applicable to selenium cyclization to produce isoselenazole derivatives. The alkoxy substituent at C3 can be used for further functionalization of the azole core.

Metal-free visible light-promoted synthesis of isothiazoles: A catalytic approach for N-S bond formation from iminyl radicals under batch and flow conditions

A sustainable synthesis of isothiazoles has been developed using an α-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance representing a new enviromenta

IRIDIUM COMPLEX AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME

The present invention discloses an iridium complex represented by the following formula (1) and an organic electroluminescence device using the iridium complex as a phosphorescent dopant material. The phosphorescent dopant material may lower a driving voltage and power consumption and increase a current efficiency and half-life of the organic electroluminescence device. The same definition as described in the present invention.

Acid-Catalyzed Synthesis of Aryl[4,5]isothiazoles through a Sulfenic Acid Pathway

A new method to efficiently prepare 3-substituted aryl[4,5]isothiazoles by simply heating the starting materials with a catalytic amount of p -toluenesulfonic acid in toluene is reported. This simple procedure is well suitable for a variety of substrates

Preparation of Thioanisole Biscarbanion and C-H Lithiation/Annulation Reactions for the Access of Five-Membered Heterocycles

The synthesis, isolation, and X-ray structure of a thioanisole-based trilithium complex are reported. On the basis of the double-lithiation strategy, two novel synthetic methodologies have been developed under mild reaction conditions (room temperature): (1) reactions of lithiated thioanisoles with nitriles give benzoisothiazoles via a [3 + 2]-type of approach with two new bond formations and (2) formation of benzothiophenes from thioanisoles and amides through a [4 + 1] pattern forming 4 new chemical bonds.

Preparation method of benzisothiazole derivative

The invention discloses a preparation method of a benzisothiazole derivative. The method comprises the following steps that a benzyl disulfide (I), N,N,N',N'-tetramethylethylenediamine (II) and a C1-C10 lithium alkylide (III) normal hexane solution are sequentially added into a solvent, reaction, filtering and drying are performed to obtain di-lithium compound white powder, the di-lithium compound and a cyano compound (V) are subjected to a reaction under the room temperature, and the benzisothiazole derivative (VI) is obtained. The method has the advantages that operation is easy, reaction raw materials and reaction reagents are easy to obtain, product substituent groups have diversified types, and the yield is high.

Synthesis of 3-Substituted Aryl[4,5]isothiazoles through an All-Heteroatom Wittig-Equivalent Process

Extending the previous use of tert-butyl sulfoxide as the sulfinyl source, intramolecular sulfinylation of sulfonamides was successfully performed. The resulting sulfinimides were not isolated and instead were believed to go through an all-heteroatom Witt

Elemental step thermodynamics of various analogues of indazolium alkaloids to obtaining hydride in acetonitrile

A series of analogues of indazolium alkaloids were designed and synthesized. The thermodynamic driving forces of the 6 elemental steps for the analogues of indazolium alkaloids to obtain hydride in acetonitrile were determined using an isothermal titration calorimeter (ITC) and electrochemical methods, respectively. The effects of molecular structure and substituents on the thermodynamic driving forces of the 6 steps were examined. Meanwhile, the oxidation mechanism of NADH coenzyme by indazolium alkaloids was examined using the chemical mimic method. The result shows that the oxidation of NADH coenzyme by indazolium alkaloids in vivo takes place by one-step concerted hydride transfer mechanism.

Facile preparation of 3-substituted benzisothiazoles from o-mercaptoacylphenones

(Chemical Equetion Presentation) A synthesis of 3-substituted benzisothiazoles starting from readily available o-mercaptoacylphenones is presented. The key cyclization step features a mild S-nitrosation and its succeeding intramolecular aza-Wittig reactio

Gas-phase cyclisation reactions of 1-(2-arylthiophenyl)alkaniminyl and 2-(aryliminomethyl)thiophenoxyl radicals

Flash vacuum pyrolysis (FVP) of the oxime ethers 12-14 and of the sulfides 18-20 at 650°C (10-2-10-3 Torr) gave products derived from the corresponding iminyl and thiophenoxyl radicals. In all cases, benz[d]isothiazoles (e.g., 26) are formed as major products via SHi mechanisms though the yields are greatest with the iminyl precursors. Alternative pathways observed from the thiophenoxyls in specific cases include the formation of the anilinobenzothiophene 36 and of dibenzothiophene 23, via an SHi process and a spirodienyl rearrangement, respectively. There is no evidence for signicant interconversion of the iminyl and thiophenoxyl species.