70150-66-2

Upstream product

• 28495-21-8 1,5-dimethoxy-3-methyl-1,4-cyclohexadiene 
• 1694-31-1 tert-butyl acetoacetate 
• 10544-63-5 ethyl crotonate 
• 29654-55-5 5-(hydroxymethyl)benzene-1,3-diol 

Downstream Products

• 35023-83-7 3-ethoxy-5-methyl-cyclohex-2-enone 
• 155625-78-8 3-(2-Methoxy-phenylamino)-5-methyl-cyclohex-2-enone 
• 148278-40-4 3-Benzylamino-5-methyl-cyclohex-2-enone 
• 56576-02-4 2-allyl-5-methylcyclohexa-1,3-dione 
• 125787-54-4 3-bromo-5-methylcyclohex-2-enone 
• 897657-79-3 3-((5-methylisoxazol-3-yl)amino)-5-methylcyclohex-2-enone 
• 1377150-69-0 3-[(5-methylisoxazol-4-yl)methylamino]-5-methylcyclohex-2-enone 
• 1377150-72-5 5-methyl-N-(5-methyl-3-oxocyclohex-1enyl)isoxazole-3-carboxamide 
• 54398-84-4 1-Amino-5-methylcyclohex-1-en-3-one 
• 129611-12-7 5-methyl-3-trimethylsilyloxycyclohex-2-en-1-one 
• 123271-59-0 C₁₇H₂₂O₅ 
• 3209-13-0 O-methylorcinol 
• 7214-50-8 5-methylcyclohex-2-en-1-one 
• 123272-11-7 3-(2-Hydroxy-4-methyl-6-oxo-cyclohex-1-enyl)-2,6-dimethyl-1-phenyl-1,5,6,7-tetrahydro-indol-4-one 

Relevant academic research and scientific papers

N-phenyl and N-benzyl enaminones and methods for using same

The present disclosure provides compounds, compositions, and methods for use of the compounds. The compounds are N-phenyl or N-benzyl enaminones. The compositions can be pharmaceutical compositions. For example, the compounds/compositions are used in treating seizure disorders. The methods entail administering a composition comprising one or more of the compounds to a subject in need thereof. Articles of manufacture comprising one or more of the compounds/compositions are also provided.

Total synthesis of (+)-nankakurines A and B and (±)-5-epi- nankakurine A

The first total syntheses of the Lycopodium alkaloids (+)-nankakurine A (2), (+)-nankakurine B (3), and the originally purported structure 1 of nankakurine A were accomplished. The syntheses of 2 and 3 feature a demanding intramolecular azomethine imine cycloaddition as the key step for generating the octahydro-3,5-ethanoquinoline moiety and installing the correct relative configuration at the spiropiperidine ring juncture. The cyclization precursor was prepared from octahydronaphthalene ketone 50, which was assembled from enone (+)-9 and diene 48 by a cationic Diels-Alder reaction. The Diels-Alder reactants were synthesized from 5-hexyn-1-ol (16) and (+)-pulegone (49), respectively. The tetracyclic ring system of 1 was generated using an unprecedented nitrogen-terminated aza-Prins cyclization cascade. The enantioselective total syntheses of (+)-nankakurine A (2) and (+)-nankakurine B (3) establish the relative and absolute configuration of these alkaloids and are sufficiently concise that substantial quantities of 2 and 3 were prepared for biological studies. (+)-Nankakurine A and (+)-nankakurine B showed no effect on neurite outgrowth in rat hippocampal H-19 cells over a concentration range of 0.3-10 μM.

Cytochalasin Support Studies. The C14-C19 Subunit of Cytochalasin C. Intramolecular 2 + 2 Photochemical Cycloaddition of Vinyl Sulfones

An intramolecular 2? + 2? photochemical cycloaddition between a six-membered ring vinyl sulfone and a five-membered ring vinylogous ester is described.The process occurs with moderate regiospecificity, the direction being controlled by a cis-acetonide moiety on the six-membered ring.Attempts to fragment the β-alkoxy sulfone adduct to trigger a DeMayo ring expansion were unsuccessful.