70175-90-5Relevant articles and documents
Method for synthesizing latamoxef side chain
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Paragraph 0058; 0059; 0060; 0061, (2018/04/03)
The invention relates to a method for synthesizing a latamoxef side chain. The method comprises the following steps: 1. dissolving p-hydroxyphenylacetic acid and p-methoxybenzyl alcohol in an inert solvent and using immobilized lipase to perform biocatalytic esterification in a reactor, and obtain a latamoxef side chain intermediate I after dewatering; 2. dissolving the latamoxef side chain intermediate I and p-methoxybenzyl alcohol in an inert solvent and using immobilized laccase to perform biocatalytic etherification to obtain a latamoxef side chain intermediate II; 3. subjecting the latamoxef side chain intermediate II to carbonylation to obtain the latamoxef side chain 4-(4-methoxybenzyloxy)phenylmalonic acid-4-methoxybenzyl monoester. The synthesis method solves the environmental protection problem of generating large amount of waste acid water and alkaline waste residues, and has the advantages of simultaneously reducing the energy consumption and the production cost, and increasing the yield and purity of the product.