701975-47-5Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity
Coelho, Alberto,Ravi?a, Enrique,Fraiz, Nuria,Yá?ez, Matilde,Laguna, Reyes,Cano, Ernesto,Sotelo, Eddy
, p. 6476 - 6484 (2008/09/17)
5-Alkylidenepyridazin-3-ones with four points of diversity (R2, R6, X, Y) have been synthesized and evaluated as platelet aggregation inhibitors. Several derivatives eliciting antiplatelet activity in the low micromolar range (e.g.,
