701976-54-7 Usage
Enzyme inhibitor
This phosphatidylinositol analogue (FWfree-acid = 598.76 g/mol), also known as SH-5, inhibits the proto-oncogenic serine/threonine kinase Akt (protein kinase B), inducing apoptosis. Specific inhibition of Akt by these compounds validates ligand design targeted to the PH domains of crucial signaling proteins, thus providing a unique class of possible cancer therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 701976-54-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,1,9,7 and 6 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 701976-54:
(8*7)+(7*0)+(6*1)+(5*9)+(4*7)+(3*6)+(2*5)+(1*4)=167
167 % 10 = 7
So 701976-54-7 is a valid CAS Registry Number.
701976-54-7Relevant articles and documents
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt
Kozikowski, Alan P.,Sun, Haiying,Brognard, John,Dennis, Phillip A.
, p. 1144 - 1145 (2007/10/03)
The synthesis from l-quebrachitol of a series of 3-deoxygenated ether lipid-type phosphatidylinositol (PI) analogues is reported, that selectively block activation of Akt and downstream substrates without affecting activation of the upstream kinase, PDK-1
