70200-79-2

Upstream product

• 20884-21-3 3,4-dihydro-2,2-dimetyl-3,5-diphenyl-2H-pyrrole-1-oxide 
• 98-88-4 benzoyl chloride 
• 13466-32-5 acetophenone dimethylhydrazone 
• 14491-02-2 2,2-dimethyl-3-phenyl-2H-azirine 
• 70078-39-6 2,2-dimethyl-3,5-diphenyl-pyrrolidine 
• 20894-11-5 4-methyl-4-nitro-1,3-diphenylpentan-1-one 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 136344-30-4 3-methyl-4-nitro-1,3-diphenylpentan-1-one 
• 128260-01-5 3-methyl-1,3-diphenylpentane-1,4-dione 
• 126280-21-5 2,3-dimethyl-3,5-diphenyl-3H-pyrrole 
• 72001-14-0 2,3-dimethyl-2,5-diphenyl-2H-pyrrole 

Downstream Products

• 107902-03-4 5,5-Dimethyl-6,7a-diphenyl-5,7a-dihydro-3H-pyrrolizine-1,2-dicarboxylic acid dimethyl ester 
• 123372-00-9 (E)-2-(5-Hydroxy-2,2-dimethyl-3,5-diphenyl-2,5-dihydro-pyrrol-1-yl)-but-2-enedioic acid dimethyl ester 
• 107902-05-6 (1R,7aR)-5,5-Dimethyl-6,7a-diphenyl-2,3,5,7a-tetrahydro-1H-pyrrolizine-1-carboxylic acid methyl ester 
• 107902-10-3 Trifluoro-methanesulfonate1,2,2-trimethyl-3,5-diphenyl-2H-pyrrolium; 
• 136215-74-2 5,5-Dimethyl-1,3,6,7a-tetraphenyl-5,7a-dihydro-1H-pyrrolo[2,1-c][1,2,4]triazole 
• 136197-88-1 5,5-Dimethyl-3,6,7a-triphenyl-5,7a-dihydro-pyrrolo[1,2-d][1,2,4]oxadiazole 

Relevant academic research and scientific papers

Synthesis of 2H-pyrroles by treatment of pyrrolidines with DDQ

A mild and efficient synthesis of 2,2-dialkyl-3,5-diaryl-2H-pyrroles is described. Treatment of 2,2-dialkyl-3,5-diarylpyrrolidines with DDQ in dioxane for 12-24 h at rt afforded the corresponding 2H-pyrroles in 55-81% overall yields.

THE SYNTHESIS AND CHEMISTRY OF AZOLENINES. PART 21. REVERSIBLE INTERCONVERSIONS OF ISOMERIC 2H- AND 3H-PYRROLES DURING THERMAL REARRANGEMENT INTO 2,3-DIMETHYL-4,5-DIPHENYL-1H-PYRROLE

Thermal rearrangments of 2,3-dimethyl-2,5-diphenyl-2H-pyrrole 1 and 2,3-dimethyl-3,5-diphenyl-3H-pyrrole 3 at 270 deg C for 12 h yield the same product 2,3-dimethyl-4,5-diphenyl-1H-pyrrole 5.On heating either 1 or 3 for only 1 h, four isomeric 2H- and 3H-pyrroles are observed, demonstrating the facile interconversion of these compounds prior to non-reversible rearrangment into the 1H-pyrrole 5.No traces of other 1H-pyrrole isomers were detected.

Nitrones and Oxaziridines. XXXIX Conversion of 1-Pyrroline 1-Oxides into 2H-Pyrroles through the Hetero-Cope Rearrangement

The 1-pyrroline 1-oxides (1) undergo a hetero-Cope rearrangement to give variously the 2H-pyrroles (2) and/or the 3-benzoyloxy-1-pyrrolines (3).The esters (3) can be hydrolysed to the corresponding alcohols (4).

REACTION OF CHLOROSULFONYL ISOCYANATE WITH NITRONES: AN EFFICIENT METHOD FOR THE SYNTHESIS OF CYCLIC ENAMIDES AND 2H-PYRROLES

Reaction of chlorosulfonyl isocyanate (CSI) with nitrones (derived from cyclic conjugated ketones), 1-7 and 3,4-dihydro-2H-pyrrole-1-oxides, 15a-f, has been studied.Nitrones, 1-7, react with CSI to form the enamides, 8, 10-14, and the cyclic amide, 9, in

CONVERSION OF 3,4-DIHYDRO-2H-PYRROLE-1-OXIDE TO 2H-PYRROLE USING CHLOROSULFONYL ISOCYANATE

3,4-Dihydro-2H-pyrrole-1-oxides 1a-e react with Chlorosulfonyl isocyanate (CSI), to give the 2H-pyrroles 2a-e. 3,4-Dihydro-2,2,4,4-tetramethyl-2H-pyrrole-1-oxide 1f on treatment with CSI furnished 3,3,5,5-tetramethyl pyrrolidin-2-one.