70223-77-7

Usage

Uses

Used in Pharmaceutical Industry:
(1S,2S)-(+)-1,2-BIS(DIPHENYLPHOSPHINOMETHYL)CYCLOHEXANE is used as a ligand in asymmetric catalysis for the production of enantiomerically pure pharmaceutical compounds. Its ability to selectively control the stereochemistry of reactions is essential in synthesizing complex organic molecules with specific biological activities, contributing to the development of more effective and safer medications.
Used in Agrochemical Industry:
In the agrochemical industry, (1S,2S)-(+)-1,2-BIS(DIPHENYLPHOSPHINOMETHYL)CYCLOHEXANE serves as a ligand in asymmetric catalysis for the synthesis of enantiomerically pure agrochemical compounds. The selective control of stereochemistry allows for the production of more effective and environmentally friendly pesticides and other agrochemicals, enhancing crop protection and yield while minimizing potential side effects on non-target organisms and the environment.

Upstream product

• 610-10-6 (1S,2S)-cyclohexane-1,2-dicarboxylic acid 

Relevant academic research and scientific papers

Development of effective bidentate diphosphine ligands of ruthenium catalysts toward practical hydrogenation of carboxylic acids

Hydrogenation of carboxylic acids (CAs) to alcohols represents one of the most ideal reduction methods for utilizing abundant CAs as alternative carbon and energy sources. However, systematic studies on the effects of metal-to-ligand relationships on the catalytic activity of metal complex catalysts are scarce. We previously demonstrated a rational methodology for CA hydrogenation, in which CA-derived cationic metal carboxylate [(PP)M(OCOR)]+ (M = Ru and Re; P = one P coordination) served as the catalyst prototype for CA self-induced CA hydrogenation. Herein, we report systematic trial- and-error studies on how we could achieve higher catalytic activity by modifying the structure of bidentate diphosphine (PP) ligands of molecular Ru catalysts. Carbon chains connecting two P atoms as well as Ar groups substituted on the P atoms of PP ligands were intensively varied, and the induction of active Ru catalysts from precatalyst Ru(acac)3 was surveyed extensively. As a result, the activity and durability of the (PP)Ru catalyst substantially increased compared to those of other molecular Ru catalyst systems, including our original Ru catalysts. The results validate our approach for improving the catalyst performance, which would benefit further advancement of CA self-induced CA hydrogenation.

An Efficient Procedure for the Synthesis of C-Chiral Bisphosphines.

A practical method for the synthesis of bisphosphines containing homochiral carbon backbones is described.This procedure entails sequential reaction of a homochiral ditosylate with the appropriate dialkyl- or diarylphosphine-borane anion followed by BH3 decomplexation mediated by HBF4*OMe2.