70237-22-8

Usage

Uses

Used in Pharmaceutical Industry:
4,7-DICHLORO-3-IODOQUINOLINE is used as a key intermediate in the synthesis of 7-Chloro-3-iodo Hydroxychloroquine (C293460) and 3-Trifluoromethyl Hydroxychloroquine (T815840), which are impurities of hydroxychloroquine, an anti-malarial drug.
Used in COVID-19 Research:
4,7-DICHLORO-3-IODOQUINOLINE is also utilized as a research product in the development of potential treatments and therapies for COVID-19, contributing to the ongoing efforts to combat the pandemic.

InChI:InChI=1/C9H4Cl2IN/c10-5-1-2-6-8(3-5)13-4-7(12)9(6)11/h1-4H

Upstream product

• 860236-13-1 7-chloro-3-iodoquinolin-4-ol 
• 858468-08-3 4,7-dichloro-[3]quinolylamine 
• 21640-97-1 7-chloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester 
• 874532-82-8 7-chloro-4-hydroxy-3-iodo-quinoline-2-carboxylic acid 
• 5350-50-5 7-chloro-3-nitro-4-hydroxyquinoline 
• 22931-74-4 4,7-dichloro-3-nitroquinoline 
• 86-98-6 4,7-dichloroquinoline 
• 855634-54-7 7-chloro-4-hydroxy-3-iodo-quinoline-2-carboxylic acid ethyl ester 
• 86-99-7 7-chloro-4-hydroxylquinoline 

Downstream Products

• 1447160-79-3 7-chloro-4-ethoxy-3-(4-(trifluoromethoxy)phenyl)quinoline 
• 1422514-28-0 N₁-(tert-butyl)-N₃-(7-chloro-3-(4-(trifluoromethoxy)-phenyl)-quinolin-4-yl)propane-1,3-diamine 
• 1447160-98-6 C₂₂H₂₃ClF₃N₃O 
• 1447160-80-6 4,7-dichloro-3-(4-(trifluoromethoxy)phenyl)quinoline 

Relevant academic research and scientific papers

ANALOGUES OF HYDROXYCHLOROQUINE (HCQ) WITHOUT RETINAL TOXICITY

The present invention relates to hydroxychloroquine analogues having an activity superior to that of hydroxychloroquine but free from retinal cytotoxicity of formula (I), their pharmaceutically acceptable salts, solvates or hydrates: their method of prepa

Base-Controlled Regioselective Functionalization of Chloro-Substituted Quinolines

We prepared a number of di- and trifunctionalized quinolines by selective metalation of chloro-substituted quinolines with metal amides followed by reaction with different electrophiles. Metalation of the C-3 position of the quinolinic ring with lithium diisopropylamide at -70 °C is easy to achieve, whereas reaction with lithium-magnesium and lithium-zinc amides affords C-2 or C-8 functionalized derivatives in a regioselective fashion. These complementary methods could be rationalized by DFT calculations and are convenient strategies toward the synthesis of bioactive quinoline derivatives such as chloroquine analogues.

COMPOUNDS, COMPOSITIONS AND ASSOCIATED METHODS COMPRISING 3-ARYL QUINOLINES

Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disc