70258-77-4Relevant academic research and scientific papers
Oxidative Coupling of 3-Oxindoles with Indoles and Arenes
Kang, Houng,Jemison, Adriana L.,Nigro, Erin,Kozlowski, Marisa C.
, p. 3144 - 3151 (2019/08/01)
A highly efficient method for the oxidative coupling of 2-substituted 3-oxindoles with aromatic compounds to form 2,2-disubstituted indolin-3-ones with broad scope is described. This work utilized oxygen as the terminal oxidant and a base-metal catalyst under mild conditions instead of toxic/precious-metal reagents and higher-molecular-weight oxidants. Quaternary structures were produced in modest-to-excellent yields (up to 96 %) without prefunctionalization.
Synthesis of Novel 1-Phenyl-1H-indole-2-carboxylic Acids. I. Utilization of Ullmann and Dieckmann Reactions for the Preparation of 3-Hydroxy, 3-Alkoxy, and 3-Alkyl Derivatives
Unangst, Paul C.,Connor, David T.,Stabler, S. Russell,Weikert, Robert J.
, p. 811 - 815 (2007/10/02)
Methods for the synthesis of novel 3-hydroxy, 3-alkoxy, and 3-alkyl indole-2-carboxylic acids and esters are described.Dieckmann cyclization of various 2-benzoic acid diesters yielded 1-unsubstituted-, 1-methyl-, and 1-phenyl-3-hydro
