113525-10-3Relevant academic research and scientific papers
Oxidative Coupling of 3-Oxindoles with Indoles and Arenes
Kang, Houng,Jemison, Adriana L.,Nigro, Erin,Kozlowski, Marisa C.
, p. 3144 - 3151 (2019/08/01)
A highly efficient method for the oxidative coupling of 2-substituted 3-oxindoles with aromatic compounds to form 2,2-disubstituted indolin-3-ones with broad scope is described. This work utilized oxygen as the terminal oxidant and a base-metal catalyst under mild conditions instead of toxic/precious-metal reagents and higher-molecular-weight oxidants. Quaternary structures were produced in modest-to-excellent yields (up to 96 %) without prefunctionalization.
Stereogenic: Cis -2-substituted- N -acetyl-3-hydroxy-indolines via ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation
Luo, Zhonghua,Sun, Guodong,Zhou, Zihong,Liu, Guozhu,Luan, Baolei,Lin, Yicao,Zhang, Lei,Wang, Zhongqing
supporting information, p. 13503 - 13506 (2018/12/12)
Ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation of racemic 2-substituted-N-acetyl-3-oxoindolines to cis-2-substituted-N-acetyl-3-hydroxyindolines is reported. Using the homochiral {Ru[TfDPEN](p-cymene)} catalyst with S/C = 400 in a HCO2H/Et3N mixture, up to >99.9% ee and >99:1 dr are obtained with high yields (79-98%). This method provides the first example of preparing enantiomerically pure indolines through asymmetric transfer hydrogenation (ATH).
Synthesis of Novel 1-Phenyl-1H-indole-2-carboxylic Acids. I. Utilization of Ullmann and Dieckmann Reactions for the Preparation of 3-Hydroxy, 3-Alkoxy, and 3-Alkyl Derivatives
Unangst, Paul C.,Connor, David T.,Stabler, S. Russell,Weikert, Robert J.
, p. 811 - 815 (2007/10/02)
Methods for the synthesis of novel 3-hydroxy, 3-alkoxy, and 3-alkyl indole-2-carboxylic acids and esters are described.Dieckmann cyclization of various 2-benzoic acid diesters yielded 1-unsubstituted-, 1-methyl-, and 1-phenyl-3-hydro
