7026-47-3Relevant academic research and scientific papers
Intramolecular cation-π interactions as the driving force to restrict the conformation of certain nucleosides
Casanova, Elena,Priego, Eva-Maria,Jimeno, Maria-Luisa,Aguado, Leire,Negri, Ana,Gago, Federico,Camarasa, Maria-Jose,Perez, Maria-Jesus
experimental part, p. 1974 - 1981 (2010/05/19)
"Chemical Equation Presented" Despite the well-established importance of intermolecular cation-π interactions in molecular recognition, intramolecular cation-jr interactions have been less studied. Here we describe how the simultaneous presence of an arom
An efficient synthesis of futalosine
Li, Xu,Tanner, Martin E.
scheme or table, p. 6463 - 6465 (2010/12/25)
Futalosine is a naturally occurring nucleoside comprised of an inosine core with a 3-carboxyphenyl methylene ketone functionality replacing the C-5′ hydroxyl. Recent studies have shown that it is a key intermediate in an alternative biosynthetic pathway that generates menaquinone in a variety of bacterial species. Here we report the first synthesis of futalosine in seven steps from inosine in an overall 17% yield. This work will enable further studies on menaquinone biosynthesis in pathogenic bacteria.
