7026-47-3

Upstream product

• 100-39-0 benzyl bromide 
• 2140-11-6 2',3'-O-isopropylideneinosine 
• 31504-19-5 N¹-benzylinosine 
• 77-76-9 2,2-dimethoxy-propane 
• 58-63-9 Inosine 

Downstream Products

• 1217897-04-5 1-benzyl-5'-O-(4-methylbenzyl)-2',3'-O-isopropylideneinosine 

Relevant academic research and scientific papers

An efficient synthesis of futalosine

Futalosine is a naturally occurring nucleoside comprised of an inosine core with a 3-carboxyphenyl methylene ketone functionality replacing the C-5′ hydroxyl. Recent studies have shown that it is a key intermediate in an alternative biosynthetic pathway that generates menaquinone in a variety of bacterial species. Here we report the first synthesis of futalosine in seven steps from inosine in an overall 17% yield. This work will enable further studies on menaquinone biosynthesis in pathogenic bacteria.

Intramolecular cation-π interactions as the driving force to restrict the conformation of certain nucleosides

"Chemical Equation Presented" Despite the well-established importance of intermolecular cation-π interactions in molecular recognition, intramolecular cation-jr interactions have been less studied. Here we describe how the simultaneous presence of an arom