702702-09-8Relevant articles and documents
Asymmetric synthesis of cis-2,4-disubstituted azetidin-3-ones from metal carbene chemistry
Burtoloso, Antonio Carlos B.,Correia, Carlos Roque D.
, p. 5636 - 5646 (2007/10/03)
Several chiral cis-2,4-disubstituted azetidin-3-ones were prepared as single diastereoisomers from N-protected amino acids, employing a highly stereoselective copper carbenoid N-H insertion reaction of diazoketones. These azetidin-3-ones were then convert
Metal carbene N-H insertion of chiral α, α′-dialkyl α-diazoketones. A novel and concise method for the stereocontrolled synthesis of fully substituted azetidines
Burtoloso, Antonio Carlos B.,Correia, Carlos Roque D.
, p. 3355 - 3358 (2007/10/03)
The syntheses of all cis substituted azetidines were accomplished in few steps from L-serine in modest to high yields. The key step was based on a rhodium or copper carbenoid N-H insertion of α,α′- dialkyl-α-diazoketones to furnish cis-2,4-dial