70291-77-9Relevant academic research and scientific papers
Electrochemical synthesis method 5 - arylthiouracil compound
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Paragraph 0050-0063, (2021/07/16)
The invention discloses an electrochemical synthesis method of a 5-arylthiouracil compound. The method comprises the following steps: taking a hexafluoroisopropanol solution containing a uracil compound, aromatic thiophenol and iodized salt as an electrol
Iodine/persulfate-promoted site-selective direct thiolation of quinolones and uracils
Beukeaw, Danupat,Noikham, Medena,Yotphan, Sirilata
, (2019/09/03)
A simple and general method for direct thiolation of 4-quinolones with disulfides or thiols under I2/K2S2O8 system has been developed. Under the optimal conditions, the C–S bond coupling can take place effectively with good to decent yields and excellent regioselectivity of the S-linked products. The established metal-free site-selective approach was also applicable to transform a range of uracil substrates to the thio-substituted products under mild conditions. Further transformation to the sulfone derivatives can be conveniently performed in one-pot. These easy-to-handle protocols represent a useful and interesting synthetic alternative with good substrate scope and functional group compatibility.
Method for preparing 5-sulfur/selenium-modified uracil derivative
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Paragraph 0051-0056, (2019/05/02)
The invention belongs to the field of organic chemistry and particularly relates to a method for efficiently preparing a 5-sulfur/selenium-modified uracil derivative. The method comprises the steps ofenabling a thiophenol compound shown as a formula I or
A NaI/H2O2-Mediated Sulfenylation and Selenylation of Unprotected Uracil and Its Derivatives
Li, Xue-Dong,Gao, Yu-Ting,Sun, Ying-Jie,Jin, Xiao-Yang,Wang, Dong,Liu, Li,Cheng, Liang
supporting information, p. 6643 - 6647 (2019/09/07)
An efficient iodide-catalyzed/hydrogen peroxide mediated sulfenylation and selenylation of unprotected uracil and its derivatives with simple thiols and diselenides was established. This coupling tolerates a broad variety of functional groups to provide d
5-Phenylthioacyclouridine: A potent and specific inhibitor of uridine phosphorylase
El Kouni, Mahmoud H.,Goudgaon, Naganna M.,Rafeeq, Mohammad,Al Safarjalani, Omar N.,Schinazi, Raymond F.,Naguib, Fardos N.M.
, p. 851 - 856 (2007/10/03)
5-Phenylthioacyclouridine (PTAU or 1-[(2-hydroxyethoxy)methyl]-5-phenylthiouracil) was synthesized as a highly specific and potent inhibitor of uridine phosphorylase (UrdPase, EC 2.4.2.3). PTAU has inhibition constant (K(is)) values of 248 and 353 nM towa
