70318-34-2

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 

Downstream Products

• 1428882-83-0 C₁₇H₁₆AlN₄O⁽³⁺⁾ 

Relevant academic research and scientific papers

Designing, structural elucidation, comparison of DNA binding, cleavage, radical scavenging activity and anticancer activity of copper(I) complex with 5-dimethyl-2-phenyl-4-[(pyridin-2-ylmethylene)-amino]-1,2-dihydro-pyrazol-3-one Schiff base ligand

A novel copper(I) Schiff base complex has been synthesized and fully characterized by spectral, analytical and structural modes. Single crystal X-ray diffraction studies revealed that the copper(I) complex [CuCl(PPh 3)L] has a distorted tetrahedral geometry around the central copper(I) ion. The interaction of the ligand and the complex with CT-DNA has been explored by absorption titration method which revealed that the compounds could interact with CT-DNA through intercalation. A gel electrophoresis assay demonstrated the ability of the complex to cleave the pBR322 DNA. The antioxidative properties showed that the copper(I) complex has a strong radical-scavenging potency than ligands. Further the cytotoxic effect of the compounds examined on cancerous cell lines showed that the complex exhibited substantial anticancer activity.

Novel ruthenium(II) and (III) compounds with multidentate Schiff base chelates bearing biologically significant moieties

In this account, we report the isolation of novel ruthenium(II/III) compounds from the respective reactions of the metal precursor, trans-[RuCl 2(PPh3)3] with multidentate Schiff base ligands bearing biologically significa

Synthesis, structural, spectroscopic and biological studies of Schiff base complexes

Schiff base ligand 4-((pyridin-2- yl)methyleneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one (PDMP) and its complexes were prepared and characterized on the basis of elemental analysis, IR, mass spectra and thermogravimetric analysis. All results confirm that the complexes have 1:1 (M: PMDP) stoichiometric formula [M(PMDP)Cl2H2O ] (M?=?Cu(II), Co(II), Ni(II) and Mn(II)), [Cd(PMDP)Cl2] and the ligand behaves as a bi/tridentate forming five-membered chelating ring towards the metal ions, bonding through azomethine nitrogen/exocyclic carbonyl oxygen, azomethine pyridine nitrogen and exocyclic carbonyl oxygen. The shift in the band positions of the groups involved in coordination has been utilized to estimate the metal-nitrogen and/or oxygen bond lengths. The complexes of Co(II), Ni(II) and Cu(II) are paramagnetic and the magnetic as well as spectral data suggest octahedral geometry, whereas the Cd(II) complex is tetrahedral. The XRD studies show that both the ligand and its metal complexes (1 and 3) show polycrystalline with crystal structure. Molecular docking was used to predict the binding between PMDP ligand and the receptors. The corrosion inhibition of mild steel in 2?M HCl solution by PDMP was explored utilizing potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and (EFM) electrochemical frequency modulation method. Potentiodynamic polarization demonstrated that PDMP compound is mixed-type inhibitor. EIS spectra exhibit one capacitive loop and confirm the protective ability. The percentage of inhibition efficiency was found to increase with increasing the inhibitor concentration.

Arene ruthenium(II) complexes with chalcone, aminoantipyrine and aminopyrimidine based ligands: Synthesis, structure and preliminary evaluation of anti-leukemia activity

A series of arene ruthenium(ii) (Ru) complexes with N-monodentate (AAP) and N,O- and N,N-bidentate chelating ligands (AAPS, ADABS, AAPPA and P2P) have been synthesized and evaluated for preliminary antileukemia activity. Single crystal X-ray studies of AAP-Ru, ADABS-Ru and P2P-Ru indicates that Ru(ii) adopted a typical three-leg piano-stool geometry with pseudo-tetrahedral (AAP-Ru) and quasi-octahedral arrangements (ADABS-Ru and P2P-Ru). Supramolecular interactions (C-H?Cl, N-H?Cl and π-π) in the crystal lattice of AAP-Ru and ADABS-Ru resulted in a dimeric structure whereas P2P-Ru showed a supramolecular 1D chain. Importantly, preliminary in vitro anticancer activities for Ru-arene complexes have been evaluated against K562 (human chronic myeloid leukemia cell line) by means of MTT assay that showed strong anti-leukemic activity for AAPS-Ru (IC50 = 12.46 ± 0.47 μM) and P2P-Ru (IC50 = 11.8 ± 0.49 μM). The mechanistic studies indicated reactive oxygen species (ROS) mediated selective leukemic cells death without affecting the normal cells by AAPS-Ru. The initiation of apoptosis by AAPS-Ru treatment, particularly TNF-α induced cell death, was confirmed by pre-treatment with a selective TNF-α inhibitor.

A highly selective fluorescent probe for Al3+ based on 4-aminoantipyrine

A novel and simple Schiff base based on 2-pyridine formaldehyde and 4-aminoantipyrine was synthesized and characterized as a fluorescent probe. In the presence of Al3+, the fluorescent intensity has a dramatic enhancement over other examined metal ions in aqueous solution. The method of Job's plot indicated the formation of 1:1 complex between probe and Al 3+, and the possible binding mode of the system was also proposed. Moreover, other examined metal ions had no effect on the detection of Al 3+.

Radiosensibilizer and preparation thereof

Radiosensitizer (A) that comprises an alpha -di-imine structural element (A1) and at least one biologically active N-compartment (A2) is new. An independent claim is also included for methods of producing (A) by (a) a reamination process or (b) by a catal

Molecular structure of di-aryl-aldimines by multinuclear magnetic resonance and X-ray diffraction

The complete 1H, 13C and 15N NMR analyses for a series of 25 diaryl-aldimines containing phenyl, pyridyl, pyrazolone and furanyl moieties are described herein. Detailed evaluation of substituent chemical shift and coupling constant effects showed that interaction between the lone pair of the pyrazolone carbonyl group or the nitrogen of 2-substitued pyridines with the aldimine hydrogen increases the 1JCH value and shifts the resonance signal for this hydrogen to high frequency, in the 1H NMR spectra. The X-ray crystal structure analysis of pyrazolone substituted aldimines evidenced the planarity of the aryl groups which are conjugated with the C=N double bond. In the case of the N-(2-pyridinemethylene)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one, two rotamers were observed in the same unit cell.

Microwave-mediated synthesis of amines from heterocyclic amines and aldehydes

Imines derived from heterocyclic amines and aldehydes can be readily prepared, in a domestic microwave oven, by reaction on a basic solid support and in the absence of solvent.