70344-50-2Relevant academic research and scientific papers
Studies on 4(1H)-quinazolinones. 5. Synthesis and antiinflammatory activity of 4(1H)-quinazolinone derivatives
Ozaki,Yamada,Oine,Ishizuka,Iwasawa
, p. 568 - 576 (2007/10/02)
A number of new 4(1H)-quinazolinones were synthesized and evaluated in the carrageenin-induced paw edema test. Most of the compounds were obtained by the cyclization of the appropriately substituted anthranilamides with acid chlorides, followed by further chemical transformation. Structure-activity data suggest that 2-isopropyl-1-phenyl-, 2-cyclopropyl-1-phenyl-, and 1-isopropyl-2-phenyl-4(1H)-quinazolinones afford optimal potency and the presence of a halogen atom is preferred for activity. Adrenalectomy does not affect the antiinflammatory test results. The best result taking into account both efficacy and side effects was displayed by 1-isoproyl-(2-fluorophenyl)-4(1H)-quinazolinone.
Studies on 4(1H)-Quinazolinones. 2. Synthesis of 6a,7-Dihydro-5H-quinazolinoquinazoline-5,8(6H)-diones
Ozaki, Ken-ichi,Yamada, Yoshihisa,Oine, Toyonari
, p. 1571 - 1575 (2007/10/02)
Reaction of 2,2'-dicarbamoyldiphenylamines 5-7 with acid chlorides was investigated.Condensation of 5 with acetyl chloride, isobutyryl chloride, and phenylacetyl chloride gave 4(1H)-quinazolinones 8, 14, and 15, respectively.On the other hand, reaction of
