579-92-0

Usage

Uses

Used in Chemical Reactions:
2,2'-IMINODIBENZOIC ACID is used as a substitute for diphenylamine in reactions with oxidizing agents, providing an alternative means for chemical synthesis and analysis.
Used in Analytical Chemistry:
As an oxidation-reduction indicator, 2,2'-IMINODIBENZOIC ACID is used in strongly acidic solutions to monitor and control the progress of chemical reactions, particularly those involving redox processes.
Used in Pharmaceutical Synthesis:
2,2'-IMINODIBENZOIC ACID is used as a reagent in the synthesis of conjugates of muramyldipeptide or normuramyldipeptide with hydroxyacridine/acridone derivatives. These conjugates are known for their antitumor activity, making 2,2'-IMINODIBENZOIC ACID a valuable asset in the development of potential cancer treatments.
Used in Antitumor Applications:
In the pharmaceutical industry, 2,2'-IMINODIBENZOIC ACID plays a crucial role in the synthesis of compounds with antitumor properties, contributing to the development of new drugs and therapies for cancer treatment.

Purification Methods

Crystallise the acid from EtOH. It complexes with Cu2+ , Zn2+ , Cd2+, Co2+ and Ni2+ . [Beilstein 14 H 354, 14 I 545, 14 III 942, 14 IV 1058.]

Upstream product

• 16463-38-0 potassium 2-chlorobenzoate 
• 118-92-3 anthranilic acid 
• 118-91-2 ortho-chlorobenzoic acid 
• 34069-89-1 methyl 2‐[2‐(methoxycarbonyl)phenylamino]benzoate 
• 109-72-8 n-butyllithium 
• 124-38-9 carbon dioxide 
• 67242-17-5 2,2’-dibromodiphenylamine 
• 7647-01-0 hydrogenchloride 
• 7664-41-7 ammonia 
• 7732-18-5 water 
• 37960-65-9 potassium anthranilate 
• 88-65-3 2-bromobenzoic-acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 24782-64-7 9-Oxoacridan-4-carboxylic acid 
• 815575-15-6 2,2'-bis[N-(1S)-(1-isopropyl-2-hydroxyethyl)carbamoyl]diphenylamine 
• 815575-16-7 2,2'-bis[N-(1S)-(1-isobutyl-2-hydroxyethyl)carbamoyl]diphenylamine 
• 815575-18-9 2,2'-bis[N-(1S)-(1-benzyl-2-hydroxyethyl)carbamoyl]diphenylamine 
• 815575-17-8 2,2'-bis[N-(1S)-(1-phenyl-2-hydroxyethyl)carbamoyl]diphenylamine 
• 815575-19-0 2,2'-bis[N-(1S)-(1-tert-butyl-2-hydroxyethyl)carbamoyl]diphenylamine 
• 89023-35-8 2,2'-iminobis(hydroxymethylbenzene) 
• 485394-20-5 bis-[2-((4S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-phenyl]-amine 
• 485394-22-7 bis-[2-((4S)-4-tert-butyl-4,5-dihydro-oxazol-2-yl)-phenyl]-amine 
• 485394-21-6 bis-[2-((4S)-4-phenyl-4,5-dihydro-oxazol-2-yl)-phenyl]-amine 
• 1027046-68-9 Methanesulfonic acid (S)-2-{2-[2-((S)-1-methanesulfonyloxymethyl-2,2-dimethyl-propylcarbamoyl)-phenylamino]-benzoylamino}-3,3-dimethyl-butyl ester 

Relevant academic research and scientific papers

Identification of amino acid appended acridines as potential leads to anti-cancer drugs

In order to develop the amino acid appended acridines as potential leads for anticancer drugs, they were subjected to preliminary investigations. Screening through MTT assay as well as the phase contrast micrographs and Confocal images of immunostained C6

Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting

The construction of a multivalent ligand is an effective way to increase affinity and selectivity toward biomolecular targets with multiple-ligand binding sites. Adopting this strategy, we used a known cell-penetrating peptide (CPP) mimic as a scaffold to

Stitching of tyrosine and 10H-acridin-9-one: Turn-ON fluorescence in the narrow pH range 7.4-8.5 and intracellular labelling of cancer cells

We tailored 10H-acridin-9-one and (S)-tyrosine into 3-(4-hydroxyphenyl)-2-[(9-oxo-9,10-dihydroacridine-4-carbonyl) amino]propionic acid (2). 2 underwent pH dependent protonation/deprotonation and the effect was harnessed in terms of change in the fluoresc

Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids

A novel series of acridine-coumarin hybrids was synthesized and biologically evaluated for their potential inhibitory effect on both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The newly synthesized derivatives 9a–d have shown higher ac

Solvothermal synthesis, structure, and fluorescence properties of three d10 polymers assembled from semi-rigid V-shaped aza-bridged multicarboxylate

Hydro(solvo)thermal reactions between a new flexible multicarboxylate ligand, 2,2′-azanediyldibenzoic acid (H2L), and M(OH)2 (M = Cd, Zn) in the presence of different N-donor ancillary ligands, 4,4′-bipyridine (bpy) and pyridine (py)

N-Heterocyclic carbene (NHC)-catalyzed intramolecular benzoin condensation-oxidation

NHC-Catalyzed intramolecular benzoin condensation-oxidation is developed for the expedient synthesis of diverse cyclic 1,2-diketones incorporated in dibenzo-fused seven-membered heterocycles in good to excellent yields, under ambient conditions. The prese

Bis-aroylhydrazone based on 2,2′-bis substituted diphenylamine for synthesis of new binuclear organotin (IV) complexes: Spectroscopic characterization, crystal structures, in vitro DNA-binding, plasmid DNA cleavage, PCR and cytotoxicity against MCF7 cell

New dinuclear organotin (IV) complexes, Me4Sn2L, Ph4Sn2L and Bu4Sn2L, have been synthesized from reaction of R2SnCl2 (R?=?Me, Ph and Bu) with a 2,2′-bis-substituted di

Bis-substituted diphenylamine arylidene hydrazones for the synthesis of new binuclear organotin(IV) complexes: Crystal structure, DNA cleavage and molecular docking

Five dinuclear organotin(IV) complexes, R4Sn2La (R = Me, Ph) and R4Sn2Lb (R = Me, Ph and Bu) have been synthesized from reaction of R2SnCl2 with 2,4′- and 2,2′-bis-sub

COMPOUNDS FOR USE IN ORGANIC ELECTRONIC DEVICES

A compound of formula (I): (Formula (I)) wherein Ar1, Ar2 and Ar3 independently in each occurrence is a C6-20 aryl group or a 5-20 membered heteroaryl group which is unsubstituted or substituted with one or more

Synthesis of Novel 4-acridonecarbohydrazide derivatives and their Antimicrobial Activities

Synthesis of a library of twenty one 4-acridonecarbohydrazide was carried out under microwave-irradiations and there in-vitro antimicrobial activity were evaluated against different bacterial and fungal strain species. All twenty one derivatives were foun