7035-14-5Relevant academic research and scientific papers
Ni-Catalyzed Regioselective Alkylarylation of Vinylarenes via C(sp3)-C(sp3)/C(sp3)-C(sp2) Bond Formation and Mechanistic Studies
Kc, Shekhar,Dhungana, Roshan K.,Shrestha, Bijay,Thapa, Surendra,Khanal, Namrata,Basnet, Prakash,Lebrun, Robert W.,Giri, Ramesh
, p. 9801 - 9805 (2018/08/06)
We report a Ni-catalyzed regioselective alkylarylation of vinylarenes with alkyl halides and arylzinc reagents to generate 1,1-diarylalkanes. The reaction proceeds well with primary, secondary and tertiary alkyl halides, and electronically diverse arylzinc reagents. Mechanistic investigations by radical probes, competition studies and quantitative kinetics reveal that the current reaction proceeds via a Ni(0)/Ni(I)/Ni(II) catalytic cycle by a rate-limiting direct halogen atom abstraction via single electron transfer to alkyl halides by a Ni(0)-catalyst.
A One-Step Synthesis of 1-Halo-ω,ω-diphenylalkanes
Bunce, Richard A.,Sullivan, James P.
, p. 865 - 868 (2007/10/02)
Inverse addition of the anion derived from diphenylmethane to an excess of a 1,3- or 1,4-dihaloalkane at -78 deg C in THF provides a direct, one-step synthesis of 1-halo-ω,ω-diphenylalkanes.The chlorides can be prepared in 80-85percent purified yield while the bromides are available in yields of 60-65percent.
