7035-82-7

Upstream product

• 141-97-9 ethyl acetoacetate 
• 1011-84-3 4-nitrobenzohydroximoyl chloride 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 555-16-8 4-nitrobenzaldehdye 
• 1129-37-9 4-nitrobenzaldehyde oxime 

Downstream Products

• 1370419-21-8 ethyl 3-(4-aminophenyl)-5-methylisoxazole-4-carboxylate 
• 94785-79-2 5-methyl-3-(4-nitro-phenyl)-isoxazole-4-carboxylic acid hydroxyamide 
• 7123-64-0 5-methyl-3-(4-nitrophenyl)isoxazole-4-carboxylic acid 

Relevant academic research and scientific papers

Design, docking and synthesis of novel bromo isatin incorporated isoxazole derivatives as vegfr-2 inhibitors

Objective: To design, synthesize, in vitro Vascular Endothelial Growth Factor Receptor (VEGFR-2) assay, antiproliferative activity an Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) studies of some novel bromoisatin incorporated isoxa

NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS

A compound of the following Formula (I) is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with -N, -O, or -S adjacent to the -Ar substituent or adjacent to the point of attachment for the -Ar substituent; Ar is aryl or heteroaryl; R is -CH3, -CH2F, -CHF2 or -CH=CH2; V is -H, -CH3 or =0; W is -NO2, -CI, -Br, -CH2OH, or -CN; X is -CI, -Br, -F, -CH3, -OCH3, or -CN; Y is -CH or -N; and Z is -CH or -N. This compound is useful in compositions for the prevention and treatment of influenza virus.