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5-methyl-3-(4-nitrophenyl)-4-isoxazolecarboxylic acid is a complex organic compound with the molecular formula C11H8N2O5. It features a 4-isoxazolecarboxylic acid core, which is a heterocyclic structure containing an isoxazole ring and a carboxylic acid group. The molecule is further characterized by a methyl group at the 5-position and a 4-nitrophenyl group attached at the 3-position. The 4-nitrophenyl group introduces a nitro functional group, which is known for its reactivity and can participate in various chemical reactions. 5-methyl-3-(4-nitrophenyl)-4-Isoxazolecarboxylic acid is of interest in the field of organic chemistry and may have potential applications in the synthesis of pharmaceuticals or other specialty chemicals due to its unique structure and functional groups.

7123-64-0

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7123-64-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7123-64-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,2 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 7123-64:
(6*7)+(5*1)+(4*2)+(3*3)+(2*6)+(1*4)=80
80 % 10 = 0
So 7123-64-0 is a valid CAS Registry Number.

7123-64-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Methyl-3-(4-nitrophenyl)-1,2-oxazole-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:7123-64-0 SDS

7123-64-0Relevant academic research and scientific papers

Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators

Jumppanen, Mikael,Kinnunen, Sini M.,V?lim?ki, Mika J.,Talman, Virpi,Auno, Samuli,Bruun, Tanja,Boije Af Genn?s, Gustav,Xhaard, Henri,Aumüller, Ingo B.,Ruskoaho, Heikki,Yli-Kauhaluoma, Jari

supporting information, p. 8284 - 8310 (2019/10/11)

Transcription factors GATA4 and NKX2-5 directly interact and synergistically activate several cardiac genes and stretch-induced cardiomyocyte hypertrophy. Previously, we identified phenylisoxazole carboxamide 1 as a hit compound, which inhibited the GATA4-NKX2-5 transcriptional synergy. Here, the chemical space around the molecular structure of 1 was explored by synthesizing and characterizing 220 derivatives and structurally related compounds. In addition to the synergistic transcriptional activation, selected compounds were evaluated for their effects on transcriptional activities of GATA4 and NKX2-5 individually as well as potential cytotoxicity. The structure-activity relationship (SAR) analysis revealed that the aromatic isoxazole substituent in the southern part regulates the inhibition of GATA4-NKX2-5 transcriptional synergy. Moreover, inhibition of GATA4 transcriptional activity correlated with the reduced cell viability. In summary, comprehensive SAR analysis accompanied by data analysis successfully identified potent and selective inhibitors of GATA4-NKX2-5 transcriptional synergy and revealed structural features important for it.

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