70354-01-7Relevant academic research and scientific papers
Synthesis of Tamoxifen and 4-Hydroxytamoxifen using Super-base-metalated Propylbenzene
Olier-Reuchet, Chantal,Aitken, David J.,Bucourt, Robert,Husson, Henri-Philippe
, p. 8221 - 8224 (1995)
Propylbenzene is metalated regioselectively at the α-carbon using the n-BuLi-t-BuOK-TMEDA super-base combination; the resulting carbanion condenses with functionalised benzophenones to provide direct syntheses of tamoxifen and 4-hydroxytamoxifen.
