Tetrahedron Letters p. 8221 - 8224 (1995)
Update date:2022-08-03
Topics:
Olier-Reuchet, Chantal
Aitken, David J.
Bucourt, Robert
Husson, Henri-Philippe
Propylbenzene is metalated regioselectively at the α-carbon using the n-BuLi-t-BuOK-TMEDA super-base combination; the resulting carbanion condenses with functionalised benzophenones to provide direct syntheses of tamoxifen and 4-hydroxytamoxifen.
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