70374-37-7 Usage
Uses
Used in Pharmaceutical Industry:
Methyl 5-chloro-3-chlorosulfonyl-2-thiophene carboxylate is used as a building block or intermediate in the synthesis of various pharmaceutical compounds due to its unique structure and functional groups. The presence of chlorine atoms and the carboxylate group may allow for further chemical modifications, enabling the development of new drugs with specific therapeutic properties.
Used in Chemical Research:
Methyl 5-chloro-3-chlorosulfonyl-2-thiophene carboxylate is used as a research compound to study the properties and reactivity of organosulfur compounds, particularly thiophenes. Its unique structure and functional groups can provide insights into the behavior of similar compounds and contribute to the understanding of their potential applications in various fields.
Used in Material Science:
Methyl 5-chloro-3-chlorosulfonyl-2-thiophene carboxylate may be used in the development of new materials with specific properties, such as conductivity, stability, or reactivity. Its unique structure and functional groups can be exploited to create novel materials with potential applications in various industries, including electronics, energy, or environmental protection.
Check Digit Verification of cas no
The CAS Registry Mumber 70374-37-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,3,7 and 4 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 70374-37:
(7*7)+(6*0)+(5*3)+(4*7)+(3*4)+(2*3)+(1*7)=117
117 % 10 = 7
So 70374-37-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H8ClNO4S2/c1-9-15(11,12)4-3-5(8)14-6(4)7(10)13-2/h3,9H,1-2H3
70374-37-7Relevant academic research and scientific papers
Synthesis method of lornoxicam intermediate 5-chloro-3-methylsulfonamide thiophene-2-carboxylic acid methyl ester
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Paragraph 0041-0049; 0052-0053, (2021/04/14)
The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthetic method of a lornoxicam intermediate 5-chloro-3-methyl sulfonamide thiophene-2-carboxylic acid methyl ester. The method comprises the following steps: by taking 5-chloro-3-methyl sulfonamide thiophene-2-carboxylic acid as an initial raw material, dichloromethane as a solvent, N,N-dimethylformamide as a catalyst and thionyl chloride as a chlorination reagent, reacting to generate an acyl chloride active intermediate, then adding triethylamine and methanol, and reacting to generate the 5-chloro-3-methyl sulfonamide thiophene-2-carboxylic acid methyl ester. According to the method, thionyl chloride is used as the chlorination reagent, so that the use of phosphorus pentachloride which is a phosphorus-containing reagent in the traditional process is avoided, and the process is more environment-friendly; meanwhile, dichloromethane is used as a solvent instead of high-toxicity chloroform, so that the pollution of the process to the environment is further reduced.
