70375-83-6

Basic information

• Product Name: 1-(4-nitrophenyl)-3-methoxycarbonyl-5-phenylpyrazole
• Synonyms: 1-(4-nitrophenyl)-3-methoxycarbonyl-5-phenylpyrazole
• CAS NO: 70375-83-6
• Molecular Weight: 323.308
• Mol File: 70375-83-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-nitrophenyl)-3-methoxycarbonyl-5-phenylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-nitrophenyl)-3-methoxycarbonyl-5-phenylpyrazole(70375-83-6)
• EPA Substance Registry System: 1-(4-nitrophenyl)-3-methoxycarbonyl-5-phenylpyrazole(70375-83-6)

Safety Data

• Hazardous Substances Data: 70375-83-6(Hazardous Substances Data)

Upstream product

• 91075-68-2 C₉H₈N₂O₂ClNO₂ 
• 536-74-3 phenylacetylene 
• 39847-99-9 (Z)-methyl 2-hydroxy-4-oxo-4-phenylbut-2-enoate 
• 100-16-3 4-nitrophenylhydrazone 

Downstream Products

• 176230-86-7 4-chloro-1-(4-nitro-phenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid methyl ester 

Relevant articles and documents

When hydrazonoyl chlorides meet terminal alkynes: Regioselective copper(I)-catalysed click sequential reactions to 5-substituted pyrazoles

In the presence of catalytic amounts of copper(I) salts, terminal alkynes underwent the formation of copper(I) acetylides that enabled their nucleophilic addition onto hydrazonoyl chlorides followed by spontaneous cyclisation of the resulting alkynylhydrazone intermediate. This sequential reaction sequence was exploited as a facile and regioselective synthesis of 1,3,5-substituted pyrazoles. A catalytic cycle has been proposed accounting for the observed results.