7038-63-3

Usage

Uses

Used in Organic Synthesis:
(4,6-DICHLORO-PYRIMIDIN-2-YL)-DIETHYLAMINE is used as a reagent in organic synthesis for its strong nucleophilic properties, which facilitate the formation of various organic compounds.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (4,6-DICHLORO-PYRIMIDIN-2-YL)-DIETHYLAMINE is utilized as a reagent in the synthesis of drug intermediates, contributing to the development of new medications.
Used in Agrochemical Synthesis:
(4,6-DICHLORO-PYRIMIDIN-2-YL)-DIETHYLAMINE is also employed in the synthesis of agrochemicals, playing a role in the production of substances used in agriculture to protect crops and enhance yields.
Safety Precautions:
It is important to handle (4,6-DICHLORO-PYRIMIDIN-2-YL)-DIETHYLAMINE with care due to its potential harmful effects if ingested, inhaled, or if it comes into contact with the skin or eyes, necessitating proper safety measures during its use.

InChI:InChI=1/C31H25N7/c1-22-16-18-25(19-17-22)33-31(30-34-27-14-8-9-15-28(27)35-30)36-32-20-24-21-38(26-12-6-3-7-13-26)37-29(24)23-10-4-2-5-11-23/h2-21,33,36H,1H3

Upstream product

• 109-89-7 diethylamine 
• 4489-34-3 4,6-dichloro-2-(methylsulfonyl)pyrimidine 
• 3764-01-0 2,4,6-trichloropyrimidine 

Relevant academic research and scientific papers

Chemoselective reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and related electrophiles with amines

Chemoselective SNAr reactions of 4,6-dichloro-2-(methylsulfonyl) pyrimidine and several related electrophiles with amines and their derivatives are described. In the presence of weak bases anilines and secondary aliphatic amines selectively displace the chloride group. Deprotonated anilines and their carbonyl derivatives displace the sulfone group. Sterically and electronically unbiased primary aliphatic amines selectively displace the sulfone group in 4,6-dichloro-2-(methylsulfonyl)pyrimidine; however, their reactions with other electrophiles generally are less selective. Steric-driven selectivity explanation was proposed. Georg Thieme Verlag Stuttgart. New York.

Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2

GalR1 and GalR2 represent unique pharmacological targets for treatment of seizures and epilepsy. A novel series of 2,4,6-triaminopyrimidine derivatives were synthesized and found to have sub-micromolar affinity for GalR2. Optimization of a series of 2,4,6

HETEROARYL COMPOUNDS

This invention relates to compounds of formula (I) their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.